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Quercetin Immobilization onto Chitosan-Functionalized Fe3O4 Magnetic Nanoparticles: Biocompatible Nanomedicine for Overcoming Cancer Cells

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Abstract

Quercetin, one of the bioactive flavonoid, prevents the proliferation of various cancer cells and has anti-cancer effects. In this study, we have developed a novel functionalized Fe3O4 nanoparticle by chitosan for quercetin delivery. The magnetic nanoparticles were physicochemically characterized by FT-IR, XRD and FE-SEM. The functionalized Fe3O4 nanoparticle was obtained in spherical shape with diameter of 50 nm. Quercetin was efficiently loaded into the prepared magnetic nanoparticles and content of it was determined by the Folin–Ciocalteu assay, finding a 117.9 mg of quercetin/ of magnetic nanoparticles. The cytotoxic activity of prepared MNPs was studied by MTT assay. Quercetin loaded MNPs exhibited greater toxicity against MCF-7 cells compared to quercetin free magnetic nanoparticles. Toxicity effect of quercetin loaded MNPs against cancerous cells make them as promising candidate for further study in cancer treatment.

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Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this work was supported by the Research Council of Amol University of Special Modern Technologies.

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Authors and Affiliations

  1. Faculty of Medicinal Plants, Amol University of Special Modern Technologies, Amol, Iran

    Mahboobeh Zare & Malihe Norouzi Sarkati

  2. Cellular and Molecular Biology Research Center (CMBRC), Health Research Institute, Babol University of Medical Sciences, Babol, Iran

    Hamed Tashakkorian

  3. Department of Pharmacology, School of Medicine, Babol University of Medical Sciences, Babol, Iran

    Hamed Tashakkorian

  4. Department of Biotechnology, Amol University of Special Modern Technologies, Amol, Iran

    Somayeh Rahaiee

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  1. Mahboobeh Zare
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  2. Malihe Norouzi Sarkati
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Correspondence to Mahboobeh Zare.

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Zare, M., Sarkati, M.N., Tashakkorian, H. et al. Quercetin Immobilization onto Chitosan-Functionalized Fe3O4 Magnetic Nanoparticles: Biocompatible Nanomedicine for Overcoming Cancer Cells. J Clust Sci 33, 449–455 (2022). https://doi.org/10.1007/s10876-021-01982-0

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  • DOI: https://doi.org/10.1007/s10876-021-01982-0

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