Article

Journal of Mammary Gland Biology and Neoplasia

, Volume 14, Issue 2, pp 145-157

Open Access This content is freely available online to anyone, anywhere at any time.

Macrophages in Breast Cancer: Do Involution Macrophages Account for the Poor Prognosis of Pregnancy-Associated Breast Cancer?

  • Jenean O’BrienAffiliated withDepartment of Medicine, Division of Medical Oncology, University of Colorado DenverProgram in Cancer Biology, University of Colorado Denver
  • , Pepper SchedinAffiliated withDepartment of Medicine, Division of Medical Oncology, University of Colorado DenverProgram in Cancer Biology, University of Colorado DenverUniversity of Colorado Comprehensive Cancer Center, University of Colorado DenverAMC Cancer Research Center, University of Colorado Denver Email author 

Abstract

Macrophage influx is associated with negative outcomes for women with breast cancer and has been demonstrated to be required for metastasis of mammary tumors in mouse models. Pregnancy-associated breast cancer is characterized by particularly poor outcomes, however the reasons remain obscure. Recently, post-pregnancy mammary involution has been characterized as having a wound healing signature. We have proposed the involution-hypothesis, which states that the wound healing microenvironment of the involuting gland is tumor promotional. Macrophage influx is one of the prominent features of the involuting gland, identifying the macrophage a potential instigator of tumor progression and a novel target for breast cancer treatment and prevention.

Keywords

Tumor-associated macrophages Arginase-1 Extracellular matrix Metalloproteinases