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Mammary Gland Macrophages: Pleiotropic Functions in Mammary Development

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Journal of Mammary Gland Biology and Neoplasia Aims and scope Submit manuscript

Abstract

Mammary gland development is a complex process involving epithelial cells and supporting stromal cells. Macrophages (M∅s) are an important component of the mammary gland stroma and are critical for normal mammary gland development; however, the mechanisms by which macrophages regulate these processes are not well understood. M∅s are known to interact with numerous cell types, including epithelial cells, fibroblasts, adipocytes, and endothelial cells, all of which are significant components of mammary gland development. Therefore, the purpose of this review is to describe the interactions between M∅s and these various cell types and use this knowledge to identify potential functions of M∅s in the mammary gland.

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Abbreviations

M∅:

macrophage

TEB:

terminal end bud

TAM:

tumor associated macrophage

ECM:

extracellular matrix

LPS:

lipopolysaccharide

IFN:

interferon

IL:

interleukin

TGF:

transforming growth factor

CSF-1:

colony stimulating factor-1

CSF-1R:

colony stimulating factor-1 receptor

DT:

diphtheria toxin

MMTV:

mouse mammary tumor virus

EGF:

epidermal growth factor

PyMT:

polyoma middle T

FGF:

fibroblast growth factor

WAT:

white adipose tissue

TNF:

tumor necrosis factor

VEGF:

vascular endothelial growth factor

TP:

thymidine phosphorylase

PGE2 :

prostaglandin E2

PDGF:

platelet derived growth factor

MMP:

matrix metalloproteinase

IGF:

insulin-like growth factor

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Acknowledgments

K.L.S. was supported by a Ruth L. Kirschstein National Research Service Award (CA 097676). This work was supported by NIH grant CA16303 to J.M.R. and NIH grant R01 HL69459 and the Kentucky Lung Cancer Research Program to D.A.C.

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Authors and Affiliations

  1. Department of Lab Medicine and Pathology, University of Minnesota Cancer Center, 420 Delaware St. SE, MMC 609, Minneapolis, MN, 55455, USA

    Kathryn L. Schwertfeger

  2. Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Jeffrey M. Rosen

  3. Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, 40536, USA

    Donald A. Cohen

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  1. Kathryn L. Schwertfeger
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  2. Jeffrey M. Rosen
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  3. Donald A. Cohen
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Correspondence to Kathryn L. Schwertfeger.

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Schwertfeger, K.L., Rosen, J.M. & Cohen, D.A. Mammary Gland Macrophages: Pleiotropic Functions in Mammary Development. J Mammary Gland Biol Neoplasia 11, 229–238 (2006). https://doi.org/10.1007/s10911-006-9028-y

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