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Magnetic microparticle steering within the constraints of an MRI system: proof of concept of a novel targeting approach

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Abstract

This paper presents a magnetic microparticle steering approach that relies on improved gradient coils for Magnetic Resonance Imaging (MRI) systems. A literature review exposes the motivation and advantages of this approach and leads to a description of the requirements for a set of dedicated steering gradient coils in comparison to standard imaging coils. An experimental set-up was developed to validate the mathematical models and the hypotheses arising from this targeting modality. Magnetite Fe3O4 microparticles (dia. 10.9 μm) were steered in a Y-shaped 100 μm diameter microchannel between a Maxwell pair (dB/dz = 443 mT/m) located in the center of an MRI bore with 0.525 m/s mean fluid velocity (ten times faster than in arterioles with same diameter). Experimental results based on the percentage of particles retrieved at the targeted outlet show that the mathematical models developed provide an order of magnitude estimate of the magnetic gradient strengths required. Furthermore, these results establish a proof of concept of microparticle steering using magnetic gradients within an MRI bore for applications in the human cardiovascular system.

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Acknowledgments

The authors wish to thank Pr. Daniel Therriault and Jean-François Dufresne for their support in the design and fabrication of the microvascular networks, Pr. David Ménard and Louis-Philippe Carignan for VSM measurements and Mahmood Mohammadi for his support with the light absorption measurements.

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Authors and Affiliations

  1. Department of Computer Engineering and the Institute of Biomedical Engineering, NanoRobotics Laboratory, École Polytechnique de Montréal (EPM), Montréal, Québec, Canada

    Jean-Baptiste Mathieu & Sylvain Martel

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  1. Jean-Baptiste Mathieu
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  2. Sylvain Martel
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Correspondence to Sylvain Martel.

Additional information

This project is supported in part by a Canada Research Chair (CRC) in Micro/Nanosystem Development, Fabrication and Validation, the Canada Foundation for Innovation (CFI), the National Sciences and Engineering Research Council of Canada (NSERC), Fonds Québécois de la Recherche sur la Nature et les Technologies (FQRNT), Fonds de la Recherche en Santé du Québec (FRSQ) and the Government of Québec.

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Mathieu, JB., Martel, S. Magnetic microparticle steering within the constraints of an MRI system: proof of concept of a novel targeting approach. Biomed Microdevices 9, 801–808 (2007). https://doi.org/10.1007/s10544-007-9092-0

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