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Prevention of postoperative tendon adhesion by biodegradable electrospun membrane of poly(lactide-co-glycolide)

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Abstract

An electrospun poly(lactide-co-glycolide) (PLGA) membrane was prepared and used to perform the anti-adhesion of Achilles tendon. Throughout the experiments, the membrane showed an appropriate degradation rate, and the pH values of degradation media were maintained at around 7.4. Simultaneously, the excellent biocompatibility of the membrane in vitro and in vivo was confirmed by live/dead and histopathological analyses. Meanwhile, the membrane can reduce tendon adhesion significantly and promote functional recovery effectively. The encouraging results were further demonstrated by hematoxylin and eosin (H&E), and Masson’s trichrome stainings, and type I collagen immunohistochemical analysis. It was concluded that the model treated with the electrospun PLGA membrane was significantly better with respect to the adhesion prevention and tissue repair than that without treatment. Considering the results of degradation and adhesion prevention efficacy, the electrospun PLGA membrane would be a great candidate for the prevention of postoperative tendon adhesion.

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Authors and Affiliations

  1. Department of Sports Medicine, First Hospital of Jilin University, Changchun, 130021, China

    Zhi-ming Song & Xiao-nan Zhang

  2. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Bo Shi, Jian-xun Ding  (丁建勋), Xiu-li Zhuang & Xue-si Chen

  3. Department of Spine Surgery, First Hospital of Jilin University, Changchun, 130021, China

    Bo Shi & Chang-feng Fu  (付长峰)

  4. Changchun SinoBiomaterials Co., Ltd., Changchun, 130103, China

    Jian-xun Ding  (丁建勋), Xiu-li Zhuang & Xue-si Chen

Authors
  1. Zhi-ming Song
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  2. Bo Shi
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  3. Jian-xun Ding  (丁建勋)
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  4. Xiu-li Zhuang
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  5. Xiao-nan Zhang
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  6. Chang-feng Fu  (付长峰)
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  7. Xue-si Chen
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Corresponding authors

Correspondence to Jian-xun Ding  (丁建勋) or Chang-feng Fu  (付长峰).

Additional information

This work was financially supported by the National Natural Science Foundation of China (Nos. 51303174, 51321062, 51233004, 51390484, 51273196, and 51203153) and the Scientific Development Program of Jilin Province (No. 20140520050JH).

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Song, Zm., Shi, B., Ding, Jx. et al. Prevention of postoperative tendon adhesion by biodegradable electrospun membrane of poly(lactide-co-glycolide). Chin J Polym Sci 33, 587–596 (2015). https://doi.org/10.1007/s10118-015-1611-5

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  • DOI: https://doi.org/10.1007/s10118-015-1611-5

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