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Biodegradable thermogel as culture matrix of bone marrow mesenchymal stem cells for potential cartilage tissue engineering

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Abstract

Poly(lactide-co-glycolide)-poly(ethylene glycol)-poly(lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer was synthesized through the ring-opening polymerization of LA and GA with PEG as macroinitiator and stannous octoate as catalyst. The amphiphilic copolymer self-assembled into micelles in aqueous solutions, and formed hydrogels as the increase of temperature at relatively high concentrations (> 15 wt%). The favorable degradability of the hydrogel was confirmed by in vitro and in vivo degradation experiments. The good cellular and tissular compatibilities of the thermogel were demonstrated. The excellent adhesion and proliferation of bone marrow mesenchymal stem cells endowed PLGA-PEG-PLGA thermogelling hydrogel with fascinating prospect for cartilage tissue engineering.

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Authors and Affiliations

  1. Department of Orthopedics, the Second Hospital of Jilin University, Changchun, 130041, China

    Yan-bo Zhang, Fei Chang  (常非) & Jin-cheng Wang  (王金成)

  2. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Yan-bo Zhang, Jian-xun Ding  (丁建勋), Wei-guo Xu, Jie Wu, Xiu-li Zhuang & Xue-si Chen

  3. Changchun SinoBiomaterials Co., Ltd., Changchun, 130103, China

    Jian-xun Ding  (丁建勋), Xiu-li Zhuang & Xue-si Chen

Authors
  1. Yan-bo Zhang
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  2. Jian-xun Ding  (丁建勋)
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  3. Wei-guo Xu
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  4. Jie Wu
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  5. Fei Chang  (常非)
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  6. Xiu-li Zhuang
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  7. Xue-si Chen
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  8. Jin-cheng Wang  (王金成)
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Corresponding authors

Correspondence to Jian-xun Ding  (丁建勋), Fei Chang  (常非) or Jin-cheng Wang  (王金成).

Additional information

This work was financially supported by the National Natural Science Foundation of China (Nos. 81171681, 51233004, 51273196, 51203153 and 51303174), and the Scientific Development Program of Jilin Province (No. 20140520050JH).

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Zhang, Yb., Ding, Jx., Xu, Wg. et al. Biodegradable thermogel as culture matrix of bone marrow mesenchymal stem cells for potential cartilage tissue engineering. Chin J Polym Sci 32, 1590–1601 (2014). https://doi.org/10.1007/s10118-014-1551-5

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  • DOI: https://doi.org/10.1007/s10118-014-1551-5

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