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A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics

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Abstract

Complications arising from tendon injury include tendon sheath infection and peritendinous adhesion, in which tendon adhesion often leads to serious motor dysfunction. In this work, the electrospun membranes of poly(L-lactide) (PLA) and poly(ε-caprolactone) (PCL) with different degradation kinetics were used to investigate their efficacy for anti-adhesion toward Achilles tendon repair. Compared with the PCL membrane, the PLA sample showed a faster rate of degradation in 42 d, and all the degradation media (i.e., phosphate-buffered saline) maintained at a constant pH of around 7.4. Meanwhile, the superior biocompatibility of both the PLA and PCL membranes were proved by the in vitro cellular adhesion tests and in vivo histopathological assays. Simultaneously, the PLA membrane was more effective than the PCL sample in decreasing adhesion and promoting functional recovery. Furthermore, the experiment result was further confirmed by hematoxylin-eosin and Masson’s trichrome staining, and type I collagen immunohistochemical analysis. All results revealed that the model treated with the electrospun PLA membrane was obviously better with regard to both anti-adhesion and tendon repair than that in the PCL membrane group. Considering the results of degradation and adhesion prevention efficacy, the electrospun polyester membranes, especially the PLA one, would be applied with fascinating potential in clinical prevention of postoperative tendon adhesion.

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Authors and Affiliations

  1. Department of Sports Medicine, First Hospital of Jilin University, Changchun, 130021, China

    Zhiming Song & Xiaonan Zhang

  2. Key Laboratory of Polymer Ecomaterials; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China

    Bo Shi, Jianxun Ding, Xiuli Zhuang & Xuesi Chen

  3. Department of Spine Surgery, First Hospital of Jilin University, Changchun, 130021, China

    Bo Shi & Changfeng Fu

  4. Changchun SinoBiomaterials Co., Ltd., Changchun, 130103, China

    Jianxun Ding, Xiuli Zhuang & Xuesi Chen

Authors
  1. Zhiming Song
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  2. Bo Shi
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  3. Jianxun Ding
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  4. Xiuli Zhuang
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  5. Xiaonan Zhang
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  6. Changfeng Fu
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  7. Xuesi Chen
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Correspondence to Jianxun Ding or Changfeng Fu.

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Song, Z., Shi, B., Ding, J. et al. A comparative study of preventing postoperative tendon adhesion using electrospun polyester membranes with different degradation kinetics. Sci. China Chem. 58, 1159–1168 (2015). https://doi.org/10.1007/s11426-015-5425-7

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  • DOI: https://doi.org/10.1007/s11426-015-5425-7

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