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Sesquiterpene lactones and scopoletins from Artemisia scoparia Waldst. & Kit. and their angiotensin I-converting enzyme inhibitory activities

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Abstract

Ten compounds, including a new guaiane-type sesquiterpene lactone, were isolated from the aerial parts of Artemisia scoparia. The structure of the new compound was determined to be 5-hydroxyguaia-3(4),11(13),10(14)-trien-6α,12-olide, named scoparanolide. Six known sesquiterpene lactones [estafiatone, 3β,4α-dihydroxyguaia-11(13),10(14)-dien-6α,12-olide, estafiatin, preeupatundin, 3β-hydroxycostunolide, and ludovicin B] and three known coumarin derivatives (scopoletin, scoparone, and isofraxidin) were identified by nuclear magnetic resonance and electrospray ionization mass spectroscopy. Six known sesquiterpene lactones were found for the first time in this plant. The angiotensin I-converting enzyme inhibitory activities of coumarin derivatives and scopoletins were significantly higher compared to those of sesquiterpene lactones and quercetin.

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Authors and Affiliations

  1. Department of Food Biotechnology and Solar Salt Research Center, Mokpo National University, Muan, Jeonnam, 58554, Korea

    Jeong-Yong Cho, Seung-Jae Jeong, Hee La Lee, Kyung-Hee Park, Do Young Hwang, Sun-Young Park & Kyung-Sik Ham

  2. Department of Food Science & Technology, and Functional Food Research Center, Chonnam National University, Gwangju, 61186, Korea

    Yu Geon Lee & Jae-Hak Moon

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  1. Jeong-Yong Cho
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  2. Seung-Jae Jeong
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Correspondence to Kyung-Sik Ham.

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Cho, JY., Jeong, SJ., Lee, H.L. et al. Sesquiterpene lactones and scopoletins from Artemisia scoparia Waldst. & Kit. and their angiotensin I-converting enzyme inhibitory activities. Food Sci Biotechnol 25, 1701–1708 (2016). https://doi.org/10.1007/s10068-016-0261-x

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  • DOI: https://doi.org/10.1007/s10068-016-0261-x

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