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A simple one-pot synthesis of quinoline-4-carboxylic acid derivatives by Pfitzinger reaction of isatin with ketones in water

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Abstract

An improved Pfitzinger condensation reaction performed under acidic conditions is established. It provides a simple and efficient synthetic method for some useful quinoline-4-carboxylic acid derivatives using isatins and ketones that cannot be obtained easily under ordinary conditions. The generality of this methodology and the catalysts used for this protocol are explored in this paper. Structures of all the synthesized compounds are characterized by spectral data.

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Acknowledgments

This project was supported by the National Natural Science Foundation of China (81172952), the Natural Science Programmes of the Education Department of Henan Province (2010B32007) and the fund of key disciplines in Xinxiang Medical University (ZD200969).

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Authors and Affiliations

  1. School of Pharmacy, Xinxiang Medical University, Henan, 453003, People’s Republic of China

    Qinghua Lv, Lizhen Fang, Pengfei Wang, Chenjuan Lu & Fulin Yan

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  1. Qinghua Lv
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  2. Lizhen Fang
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  3. Pengfei Wang
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  4. Chenjuan Lu
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  5. Fulin Yan
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Correspondence to Lizhen Fang.

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Lv, Q., Fang, L., Wang, P. et al. A simple one-pot synthesis of quinoline-4-carboxylic acid derivatives by Pfitzinger reaction of isatin with ketones in water. Monatsh Chem 144, 391–394 (2013). https://doi.org/10.1007/s00706-012-0822-5

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  • DOI: https://doi.org/10.1007/s00706-012-0822-5

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