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Synthesis of functionalized quinoline derivatives via intramolecular C–H activation reactions of N-sulfonylamidines and isocyanides

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Abstract

A novel class of substituted quinolines was synthesized through a one-pot, four-component sequential reaction by intramolecular C–H activation of isocyanides with N-sulfonylamidines, catalyzed by copper(I) iodide and l-proline as a ligand in acetonitrile at room temperature. The readily available starting materials, no need for column chromatography, mild catalytic conditions, and moderate to high yields are important features of this simple one-pot reaction.

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Acknowledgements

This work was supported by the research council of the school of pharmacy, Shahid Beheshti University of medical sciences. [Grant No. 10445].

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Authors and Affiliations

  1. Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Anna Sedaghat, Manijeh Nematpour, Maryam Bayanati & Sayyed Abbas Tabatabai

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  1. Anna Sedaghat
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  2. Manijeh Nematpour
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  3. Maryam Bayanati
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  4. Sayyed Abbas Tabatabai
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Correspondence to Sayyed Abbas Tabatabai.

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Sedaghat, A., Nematpour, M., Bayanati, M. et al. Synthesis of functionalized quinoline derivatives via intramolecular C–H activation reactions of N-sulfonylamidines and isocyanides. Monatsh Chem 151, 1591–1596 (2020). https://doi.org/10.1007/s00706-020-02684-5

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  • DOI: https://doi.org/10.1007/s00706-020-02684-5

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