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Combes quinoline synthesis

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Abstract

Acid-catalyzed condensation of anilines and β-diketones to assemble quinolines. Cf. Conrad–Limpach reaction.

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Reference

  1. Combes, A. Bull. Soc. Chim. Fr. 1888, 49, 89. Alphonse-Edmond Combes (1858–1896) was born in St. Hippolyte-du-Fort, France. He apprenticed with Wurtz at Paris. He also collaborated with Charles Friedel of the Friedel-Crafts reaction fame. He became the president of the French Chemical Society in 1893 at the age of 35. His sudden death shortly after his 38th birthday was a great loss to organic chemistry.

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Li, J.J. (2014). Combes quinoline synthesis. In: Name Reactions. Springer, Cham. https://doi.org/10.1007/978-3-319-03979-4_65

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