Consensus Paper

Acta Neuropathologica

, Volume 123, Issue 4, pp 465-472

Open Access This content is freely available online to anyone, anywhere at any time.

Molecular subgroups of medulloblastoma: the current consensus

  • Michael D. TaylorAffiliated withDivision of Neurosurgery, Hospital for Sick Children, University of TorontoProgram in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto Email author 
  • , Paul A. NorthcottAffiliated withProgram in Developmental and Stem Cell Biology, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto
  • , Andrey KorshunovAffiliated withClinical Cooperation Unit Neuropathology, German Cancer Research Center
  • , Marc RemkeAffiliated withDivision of Molecular Genetics, German Cancer Research CenterDepartment of Pediatric Hematology and Oncology, Heidelberg University Hospital
  • , Yoon-Jae ChoAffiliated withDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine
  • , Steven C. CliffordAffiliated withNorthern Institute for Cancer Research, Newcastle University
  • , Charles G. EberhartAffiliated withDepartments of Pathology, Ophthalmology and Oncology, Johns Hopkins University School of Medicine
  • , D. Williams ParsonsAffiliated withDepartment of Pediatrics, Texas Children’s Cancer Center, Baylor College of Medicine
  • , Stefan RutkowskiAffiliated withDivision of Neurosurgery, Hospital for Sick Children, University of TorontoDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf
    • , Amar GajjarAffiliated withDivision of Neurosurgery, Hospital for Sick Children, University of TorontoDepartment of Oncology, St. Jude Children’s Research Hospital
    • , David W. EllisonAffiliated withDivision of Neurosurgery, Hospital for Sick Children, University of TorontoDepartment of Pathology, St. Jude Children’s Research Hospital
    • , Peter LichterAffiliated withDivision of Molecular Genetics, German Cancer Research Center
    • , Richard J. GilbertsonAffiliated withDivision of Neurosurgery, Hospital for Sick Children, University of TorontoDepartment of Developmental Neurobiology, St. Jude Children’s Research Hospital
    • , Scott L. PomeroyAffiliated withDivision of Neurosurgery, Hospital for Sick Children, University of TorontoDepartment of Neurology, Children’s Hospital Boston, Harvard Medical School
    • , Marcel KoolAffiliated withDivision of Molecular Genetics, German Cancer Research Center
    • , Stefan M. PfisterAffiliated withDivision of Molecular Genetics, German Cancer Research CenterDepartment of Pediatric Hematology and Oncology, Heidelberg University Hospital Email author 

Abstract

Medulloblastoma, a small blue cell malignancy of the cerebellum, is a major cause of morbidity and mortality in pediatric oncology. Current mechanisms for clinical prognostication and stratification include clinical factors (age, presence of metastases, and extent of resection) as well as histological subgrouping (classic, desmoplastic, and large cell/anaplastic histology). Transcriptional profiling studies of medulloblastoma cohorts from several research groups around the globe have suggested the existence of multiple distinct molecular subgroups that differ in their demographics, transcriptomes, somatic genetic events, and clinical outcomes. Variations in the number, composition, and nature of the subgroups between studies brought about a consensus conference in Boston in the fall of 2010. Discussants at the conference came to a consensus that the evidence supported the existence of four main subgroups of medulloblastoma (Wnt, Shh, Group 3, and Group 4). Participants outlined the demographic, transcriptional, genetic, and clinical differences between the four subgroups. While it is anticipated that the molecular classification of medulloblastoma will continue to evolve and diversify in the future as larger cohorts are studied at greater depth, herein we outline the current consensus nomenclature, and the differences between the medulloblastoma subgroups.

Keywords

Medulloblastoma Consensus Subgroups SHH WNT Group 3 Group 4