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Preparation of multilayer films using the negative charge of phenylboronic acid and its response to pH change, fructose, and hydrogen peroxide

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Abstract

Functional layer-by-layer (LbL) multilayer films using phenylboronic acid (PBA) have been typically prepared by exploiting the boronate ester bond between PBA and a diol polymer as the driving force. However, we have prepared PBA-containing LbL films through the electrostatic interaction of PBA and polycations, Poly(acrylamide-ran-3-acrylamidephenylboronic acid) (PBA-PAA) and various polycations such as poly(allylamine) hydrochloride (PAH), poly(ethyleneimine) (PEI), poly(diallyldimethylammonium chloride) (PDDA), and polyamidoamine (PAMAM) dendrimer were used. Construction of the multilayer films was influenced by the modification ratio of PBA, the shape of the polycations, solution pH, and the ion concentration. The results showed that the multilayered film was formed by electrostatic interaction. A multilayer film prepared from 10% PBA containing PBA-PAA and PAH showed pH, fructose, and H2O2 responses because these stimuli disturbed the charge balance inside the multilayer films. Such decomposition responses were comparable to that of PBA multilayer films constructed using boronate ester bonds.

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Funding

The authors appreciate financial support in the form of Grants-in-Aid for Scientific Research (Nos. 16K08189 and 18 K06791) from the Japan Society for the Promotion of Science (JSPS).

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aramaki, Aoba-ku, Sendai, 980-8578, Japan

    Yuki Oide, Miku Iwasaki & Katsuhiko Sato

  2. School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima, 963-8611, Japan

    Kentaro Yoshida

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  1. Yuki Oide
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  2. Miku Iwasaki
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  4. Katsuhiko Sato
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Correspondence to Katsuhiko Sato.

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Oide, Y., Iwasaki, M., Yoshida, K. et al. Preparation of multilayer films using the negative charge of phenylboronic acid and its response to pH change, fructose, and hydrogen peroxide. Colloid Polym Sci 296, 1573–1580 (2018). https://doi.org/10.1007/s00396-018-4380-1

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  • DOI: https://doi.org/10.1007/s00396-018-4380-1

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