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Preparation of H2O2-induced poly (amidoamine) dendrimer-release multilayer films

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Abstract

Poly (amidoamine) (PAMAM) dendrimer-release multilayer films were prepared using phenylboronic acid-modified PAMAM dendrimers (PBA-D) and poly (vinyl alcohol) (PVA) through boronate ester bonds. The (PBA-D/PVA)10 film was stable in pH 9.0 solution. Upon addition of H2O2, PAMAM dendrimers were released from the (PBA-D/PVA)10 film due to oxidative scission of the carbon-boron bond in the PBA residues in PBA-D. For example, 75 and 90% of the PBA-D was released from the (PBA-D/PVA)10 film within 30 min of exposure to 0.5 and 1 mM H2O2, respectively. In addition, (PBA-D/PVA)10 films containing glucose oxidase responded to the presence of 1 mM glucose in pH 7.4 solution due to the enzymatic production of H2O2.

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Tohoku University, Aramaki, Aoba-ku, Sendai, 980-8578, Japan

    Katsuhiko Sato, Kazuma Awaji, Megumi Ito & Jun-ichi Anzai

Authors
  1. Katsuhiko Sato
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  2. Kazuma Awaji
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  3. Megumi Ito
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  4. Jun-ichi Anzai
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Correspondence to Katsuhiko Sato.

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Sources of financial funding and support

The authors appreciate the financial support from a Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (No. 16K08189).

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The authors declare that they have no conflict of interest.

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Sato, K., Awaji, K., Ito, M. et al. Preparation of H2O2-induced poly (amidoamine) dendrimer-release multilayer films. Colloid Polym Sci 295, 877–882 (2017). https://doi.org/10.1007/s00396-017-4073-1

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  • DOI: https://doi.org/10.1007/s00396-017-4073-1

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