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Photo-induced synthesis glucose-responsive carriers for controlled release of insulin in vitro

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Abstract

The glucose-responsive amphiphilic poly(PEGMA-co-AAPBA) copolymer micelles as drug carriers have been developed using 3-phenylpyruvic acid (3-PPA) as photoinitiator. Under the light irradiation, 3-PPA could be self-polymerized into the trimer structure to execute the emulsifier and initiator functions that confirmed by gas chromatography-mass spectrum (GC-MS) analysis. The structure and morphology of resultant poly(PEGMA-co-AAPBA) micelles were characterized by 1H NMR and TEM. Insulin, as the model drug of diabetes, was loaded into micelles during the photopolymerization process. The as-prepared polymeric micelles exhibited the excellent glucose sensitivity. The loaded insulin could be released from micelles triggered by regulation of temperature and glucose concentration in the environment. The new drug carriers provided a potential application for the therapy of diabetes based on glucose-sensitive controlled drug delivery systems.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (51373155) and  “521 Talents Training Plan” in Zhejiang Sci-Tech University (ZSTU).

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Authors and Affiliations

  1. Department of Materials Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, People’s Republic of China

    Xiangxiang Du & Guohua Jiang

  2. National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang), Hangzhou, 310018, People’s Republic of China

    Guohua Jiang, Lei Li, Yongkun Liu, Hua Chen & Qin Huang

  3. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Hangzhou, 310018, People’s Republic of China

    Guohua Jiang, Lei Li, Yongkun Liu, Hua Chen & Qin Huang

Authors
  1. Xiangxiang Du
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  2. Guohua Jiang
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  3. Lei Li
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  4. Yongkun Liu
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  5. Hua Chen
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Correspondence to Guohua Jiang.

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Du, X., Jiang, G., Li, L. et al. Photo-induced synthesis glucose-responsive carriers for controlled release of insulin in vitro. Colloid Polym Sci 293, 2129–2135 (2015). https://doi.org/10.1007/s00396-015-3625-5

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  • DOI: https://doi.org/10.1007/s00396-015-3625-5

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