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Assessment of myocardial fibrosis and coronary arteries in hypertrophic cardiomyopathy using combined arterial and delayed enhanced CT: comparison with MR and coronary angiography

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Abstract

Objectives

We sought to determine the feasibility and accuracy of dual-source computed tomography (DSCT) in assessing coronary artery disease and myocardial fibrosis of hypertrophic cardiomyopathy (HCM) compared with cardiac magnetic resonance (CMR) imaging and coronary angiography (CA).

Methods

Forty-seven consecutive patients with HCM were prospectively enrolled. DSCT images were acquired in the arterial and late phases following intravenous contrast medium. The CMR and CA were performed within 7 days. Independent blinded readers read each study. Patients were classified according to myocardial delayed enhanced (MDE) CMR, coronary artery stenosis by CA, and arterial and MDE-DSCT. The diagnostic accuracy of DSCT in detecting coronary stenosis and MDE was analysed.

Results

Wall thickness determined by DSCT was strongly correlated with MR results (r = 0.91). DSCT and CMR MDE showed substantial agreement for the detection of myocardial fibrosis on per-patient and per-segment levels. The CT classification of patients by arterial stenosis and delayed enhancement had excellent agreement with MR and CA methods.

Conclusions

The comprehensive cardiac CT examination provides reliable coronary artery and myocardial assessments. MDE-DSCT is a robust alternative method to MDE-CMR in assessing myocardial fibrosis in HCM particularly in patients with pacemakers or other contraindications to CMR.

Key Points

• Enhanced cardiac CT provides comprehensive assessment of patients with hypertrophic cardiomyopathy (HCM).

• Myocardial delayed enhanced-CT has comparable accuracy to MDE-MR in detecting HCM fibrosis.

• MDE-CT provides a robust alternative for HCM patients with MR contraindications.

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Abbreviations

BMI:

Body mass index

CA:

Coronary angiography

CAD:

Coronary artery disease

CCTA:

Coronary computed tomographic angiography

CMR:

Cardiac magnetic resonance

DSCT:

Dual-source computed tomography

ECG:

Electrocardiographic

HCM:

Hypertrophic cardiomyopathy

ICD:

Implanted cardiac defibrillator

MDE:

Myocardial delayed enhanced

MI:

Myocardial infarction

SSFP:

Steady state free precession

TE:

Time to echo

TR:

Time to repetition

TI:

Time to inversion

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Acknowledgements

We thank the Advanced School for Core Investigators from the Asian Society of Cardiovascular Imaging and Dr. Wen-Yih Isaac Tseng for reviewing this manuscript.

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Authors and Affiliations

  1. Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

    Lei Zhao, Xiaohai Ma, Chen Zhang, Yi Liu & Zhaoqi Zhang

  2. Division of Radiology and Biomedical Imaging, College of Human Medicine, Michigan State University, Lancing, MI, USA

    Mark C DeLano

  3. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China

    Tengyong Jiang

Authors
  1. Lei Zhao
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  2. Xiaohai Ma
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  7. Zhaoqi Zhang
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Correspondence to Xiaohai Ma.

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Zhao, L., Ma, X., DeLano, M.C. et al. Assessment of myocardial fibrosis and coronary arteries in hypertrophic cardiomyopathy using combined arterial and delayed enhanced CT: comparison with MR and coronary angiography. Eur Radiol 23, 1034–1043 (2013). https://doi.org/10.1007/s00330-012-2674-0

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  • DOI: https://doi.org/10.1007/s00330-012-2674-0

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