Review

Seminars in Immunopathology

, Volume 33, Issue 1, pp 29-43

Open Access This content is freely available online to anyone, anywhere at any time.

The pancreas in human type 1 diabetes

  • Patrick A. RoweAffiliated withDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida
  • , Martha L. Campbell-ThompsonAffiliated withDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida
  • , Desmond A. SchatzAffiliated withDepartment of Pediatrics, The University of Florida
  • , Mark A. AtkinsonAffiliated withDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida Email author 

Abstract

Type 1 diabetes (T1D) is considered a disorder whose pathogenesis is autoimmune in origin, a notion drawn in large part from studies of human pancreata performed as far back as the 1960s. While studies of the genetics, epidemiology, and peripheral immunity in T1D have been subject to widespread analysis over the ensuing decades, efforts to understand the disorder through analysis of human pancreata have been far more limited. We have reviewed the published literature pertaining to the pathology of the human pancreas throughout all stages in the natural history of T1D. This effort uncovered a series of findings that challenge many dogmas ascribed to T1D and revealed data suggesting the marked heterogeneity in terms of its pathology. An improved understanding and appreciation for pancreatic pathology in T1D could lead to improved disease classification, an understanding of why the disorder occurs, and better therapies for disease prevention and management.

Keywords

Inflammation Insulin Islet cells Pancreas T-lymphocyte Type 1 diabetes