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Clinical characteristics of pediatric HIV-1 patients treated with first-line antiretroviral therapy in Vietnam: a nested case–control study

  • Original Article
  • Published:
International Journal of Public Health

Abstract

Objectives

Over the past decades, Vietnam has made great strides in reducing the rate of mortality in HIV-related deaths, due to increased access of antiretroviral therapy (ART); however, given the significantly high level of treatment failure (TF), it is essential to identify markers that describe the failure of ART in HIV-1 infected children.

Methods

A nested case–control study was conducted with clinical data collected from 101 HIV-infected children [26 TF and 75 treatment success (TS)] at National Hospital of Pediatrics, Vietnam (2008–2012).

Results

The results showed that certain factors including height, weight, vaccination with Hepatitis B, and platelet were significantly different between TF and TS before starting the treatment. In addition, age to start the treatment, CD4 percentage, and opportunistic infection were found to significantly predict treatment outcome most frequently, implying the importance of clinical markers in the treatment response by Cox regression analysis.

Conclusions

There is an inherent complexity within clinical markers that is challenging to determine HIV-pediatric failure and further research is needed to build a complete picture to guide clinical, evidence-based practice.

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Acknowledgements

We would like to express our appreciation to Hanoi University of Public Health and National Foundation for Science and Technology Development, Ministry of Science and Technology, for financial support. We would like to thank Nguyen Manh Tien, Nguyen Huu The Tung, Tran Thi Anh, Nguyen Anh Dung, Le Nhu Hai, Luu Ly and Nguyen Tuan Anh for your valuable contribution.

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Authors and Affiliations

  1. Hanoi University of Public Health, Hanoi, Vietnam

    Minh Diem Dang, Huu Bich Tran, Thi Quynh Phan, Thi Thanh Dinh, Thi Kim Anh Le & Vu Phuong Linh Dang

  2. National Hospital of Acupuncture, Hanoi, Vietnam

    Duc Minh Nguyen, Van Lam Nguyen & Thanh Hai Le

  3. Vietnam National Hospital of Pediatrics, Hanoi, Vietnam

    Viet Hung Pham

  4. University of Buffalo School of Medicine and Biomedical Sciences, Buffalo, New York, USA

    Daryl Spak

  5. University of Washington, Seattle, Washington, USA

    Linh Chi Pham

  6. Viet Duc Hospital, Hanoi, Vietnam

    Son Ngoc Hoang

Authors
  1. Minh Diem Dang
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  2. Duc Minh Nguyen
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  3. Huu Bich Tran
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  4. Viet Hung Pham
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  5. Daryl Spak
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  6. Linh Chi Pham
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  7. Thi Quynh Phan
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  8. Thi Thanh Dinh
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  9. Thi Kim Anh Le
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  10. Van Lam Nguyen
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  11. Thanh Hai Le
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  12. Son Ngoc Hoang
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  13. Vu Phuong Linh Dang
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Corresponding author

Correspondence to Vu Phuong Linh Dang.

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Conflict of interest

Dang, Vu Phuong Linh has received research grants from Hanoi School of Public Health and National Foundation for Science and Technology Development (Nafosted), Ministry of Science and Technology. Dr. Dang acted as principal investigator of the study, developed the study design and analyzed data together with other members of research team. All authors were involved in doing research and writing of the manuscript and have approved the final version for this publication. We declare no conflict of interests.

Ethical approval

The ethical permission of the study has been approved by National Hospital of Pediatrics, Hanoi, Vietnam.

Additional information

M. D. Dang and D. M. Nguyen are first co-author.

This article is part of the supplement “Health and social determinants of health in Vietnam: local evidence and international implications”.

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Dang, M.D., Nguyen, D.M., Tran, H.B. et al. Clinical characteristics of pediatric HIV-1 patients treated with first-line antiretroviral therapy in Vietnam: a nested case–control study. Int J Public Health 62 (Suppl 1), 113–119 (2017). https://doi.org/10.1007/s00038-016-0937-2

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  • DOI: https://doi.org/10.1007/s00038-016-0937-2

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