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Vaccination and protection experiments in mice with the human A-1957 and A-1968 strains, and the Equi-2 strain of influenza virus

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Abstract

Immunization of mice with influenza virus A/Japan/305/57 (H2N2) gives protection against infection with the homologous strain, but not against infection with A/Hong Kong/1/68 (H3N2) and A/Equi/Miami/1/63 (Heq2Neq2). Immunizations with these two strains result in a protection against homologous and cross infections with A/68 or A/Equi-2/63, although there is hardly a cross-hemagglutination or neuraminidase-inhibiting antibody level. These immunizations do not protect against infection with A/57.

The presence of an unknown antigenic component (Mice Protecting Antigen: MPA) is suggested and some of its characteristics are discussed.

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Authors and Affiliations

  1. Department of Virology, Medical Faculty Rotterdam, Rotterdam, the Netherlands

    N. Masurel, A. J. Baars & Henny Frankena

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  1. N. Masurel
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  2. A. J. Baars
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  3. Henny Frankena
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In collaboration with the Chief Medical Officer of Health and Epidemiology, Department of Public Health, The Hague, the Netherlands.

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Masurel, N., Baars, A.J. & Frankena, H. Vaccination and protection experiments in mice with the human A-1957 and A-1968 strains, and the Equi-2 strain of influenza virus. Antonie van Leeuwenhoek 39, 461–471 (1973). https://doi.org/10.1007/BF02578889

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  • DOI: https://doi.org/10.1007/BF02578889

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