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Simultaneous determination of triprolidine, pseudoephedrine, paracetamol and dextromethorphan by HPLC

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Summary

A simple, rapid and specific HPLC method has been developed for the determination of triprolidine, pseudoephedrine, paracetamol and dextromethorphan, in combination, in different pharmaceutical dosage forms, using a reversed-phase C18 column, gradient elution, and UV detection at 254 and 280 nm. No preliminary extraction procedure is required for liquid formulations and a very simple extraction procedure is required for tablets and creams. The recovery of the drugs ranged from 96.0 to 98.7%. The assay results obtained for eight commercially available formulations were in agreement with the amounts declared. The linearity and precision of the method have been assessed.

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Authors and Affiliations

  1. Laboratorio di Chimica del Farmaco, Istituto Superiore di Sanità, Rome, Italy

    D. De Orsi & L. Gagliardi

  2. Dipartimento di Chimica Farmaceutica, Università di Roma “La Sapienza”, Rome, Italy

    A. Bolasco

  3. Dipartimento di Chimica Fisica ed Inorganica, Università di Bologna, Viale del Risorgimento 4, 40136, Bologna, Italy

    D. Tonelli

Authors
  1. D. De Orsi
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  2. L. Gagliardi
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  3. A. Bolasco
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  4. D. Tonelli
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De Orsi, D., Gagliardi, L., Bolasco, A. et al. Simultaneous determination of triprolidine, pseudoephedrine, paracetamol and dextromethorphan by HPLC. Chromatographia 43, 496–500 (1996). https://doi.org/10.1007/BF02293000

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  • DOI: https://doi.org/10.1007/BF02293000

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