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The restoration of the function of the hypophyseal-gonadal system following its prolonged suppression by luliberin agonists

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Conclusions

  1. 1.

    The process of the restoration of the function of the hypophyseal-gonadal system in baboons subjected to the prolonged administration of an LHRF agonist was characterized by the development of three principal phases, a latent phase, a phase of hyperfunction of the gonads, and a phase of return to the initial level of functioning.

  2. 2.

    The duration of the phases was determined by the duration of the administration of the agonist and the individual characteristics of the functioning of the hypothalamic-hypophyseal-gonadal system.

  3. 3.

    By contrast with the sex glands, the recovery of the gonadotropic function of the hypophysis did not undergo a stage of hyperfunction.

  4. 4.

    The process of restoration of the adenohypophyseal function included the development of two phases of refractoriness of the D-basophilic adenocytes to exogenous LHRF which differ in the level of their functional activity.

  5. 5.

    The recovery of the function of the hypophyseal-gonadal system in basal conditions preceded the recovery of the function of this system when it was activated.

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Authors and Affiliations

  1. Laboratory of Experimental Endocrinology of the Scientific Research Institute of Pathology and Therapy, Russian Academy of Medical Sciences, Sukhumi

    N. D. Goncharova, L. A. Mkhitarova & É. M. Gogiladze

Authors
  1. N. D. Goncharova
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  2. L. A. Mkhitarova
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  3. É. M. Gogiladze
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Translated from Problemy Éndokrinologii, Vol. 37, No. 3, pp. 45–48, May–June, 1991.

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Goncharova, N.D., Mkhitarova, L.A. & Gogiladze, É.M. The restoration of the function of the hypophyseal-gonadal system following its prolonged suppression by luliberin agonists. Neurosci Behav Physiol 23, 1–5 (1993). https://doi.org/10.1007/BF01182631

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  • DOI: https://doi.org/10.1007/BF01182631

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