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Effects of Gonadotropin-Releasing Hormone Analogue Surfagon on Pain Sensitivity in Rats

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Abstract

We investigated the effects of the synthetic gonadotropin-releasing hormone agonistic analogue surfagon on the spinal and supraspinal mechnisms of pain formation in intact and gonadectomized male Wistar rats. Alternating current painful stimulation was applied to the tail base, and pain thresholds, as well as emotional/affective responses, were recorded (in mA). Surfagon, when administred intraperitoneally 12 min before the experiments at doses 0.004–150 µg/kg, exerted an algic effect and enhanced pain-induced emotional/affective behavior in the electrocutaneous tail stimulation test. In gonadectomized rats, pain thresholds were elevated on day 12 after castration. Surfagon administration to castrated rats retained the direction of the effects observed in intact animals, indicating their steroid-independent nature. The obtained data demonstrate the presence of both spinal and supraspinal mechanisms of surfagon algic activity in rats during electrocutaneous pain stimulation.

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Funding

This work was supported by the Kursk State Medical University.

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Authors and Affiliations

  1. Kursk State Medical University, Kursk, Russia

    I. I. Bobyntsev, A. O. Vorvul, M. E. Dolgintsev & A. A. Kryukov

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  1. I. I. Bobyntsev
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  2. A. O. Vorvul
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  3. M. E. Dolgintsev
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  4. A. A. Kryukov
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Contributions

Conceptualization and experimental design (I.I.B.); data collection and processing, statistical analysis (A.O.V., M.E.D., A.A.K.); writing a manuscript (I.I.B., M.E.D.).

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Correspondence to I. I. Bobyntsev.

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The authors declare that they have no conflict of interest associated with the publication of this article.

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Translated by A. Polyanovsky

Russian Text © The Author(s), 2022, published in Rossiiskii Fiziologicheskii Zhurnal imeni I.M. Sechenova, 2022, Vol. 108, No. 1, pp. 121–128https://doi.org/10.31857/S0869813922010034.

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Bobyntsev, I.I., Vorvul, A.O., Dolgintsev, M.E. et al. Effects of Gonadotropin-Releasing Hormone Analogue Surfagon on Pain Sensitivity in Rats. J Evol Biochem Phys 58, 167–173 (2022). https://doi.org/10.1134/S002209302201015X

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