Summary
Mice were stained with pulverized charcoal and the resulting grooming behaviour observed. From 119 controls, the typical patterns indicated a late cleaning of the tail, the sacrum and the region between the ears. The following substances were tested: Imipramine, Desipramine, Trimeprimine, Amitriptyline, Nortriptyline, Chlordiazepoxide, Iproniazide, d-Amphetamine, Chlorpromazine, Haloperidol, Acetylsalicylic acid, Metronidazole. Of these Amitriptyline, Chlorpromazine, Haloperidol and Metronidazole were effective in doses less than 1/10 of LD 5.
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References
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Rohte, O. Studies of the influence of some psychotropic substances on the grooming behaviour of white mice. Psychopharmacologia 14, 18–22 (1969). https://doi.org/10.1007/BF00401530
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DOI: https://doi.org/10.1007/BF00401530