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The Effect of Noopept on the Content of Monoamines and Their Metabolites and Neurotransmitter Amino Acids in the Brain Structures of BALB/c and C57BL/6 Mice: A Comparative Study

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Abstract—The aim of this study was to compare neurochemical changes induced by the dipeptide analogue of piracetam, the ethyl ester of N-phenylacetyl-L-prolylglycine (noopept), in the brain structures of BALB/c and C57BL/6 mice with different genetically determined responses to emotional stress. It was found using the HPLC technique that noopept at doses of 0.5 and 2.5 mg/kg after acute administration reduced the content of dopamine (DA) and its metabolite homovanillic acid (HVA) in the frontal cortex of both strains of mice. In “highly anxious” BALB/c mice, noopept increased the intracellular DA turnover (DOPAC/DA) and the total DA turnover (HVA/DA) in the frontal cortex, increased the level of noradrenaline and the metabolic rate of DA and serotonin in the hypothalamus, and increased the total DA turnover in the striatum. Noopept had no effect on the content of neurotransmitter amino acids in the brain structures of mice of both strains.

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Funding

The work was supported by the Ministry of Science and Higher Education of the Russian Federation.

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Authors and Affiliations

  1. Zakusov Institute of Pharmacology, Moscow, Russia

    V. G. Kon’kov, V. S. Kudrin, V. B. Narkevich & L. G. Kolik

Authors
  1. V. G. Kon’kov
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  2. V. S. Kudrin
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  3. V. B. Narkevich
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  4. L. G. Kolik
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Corresponding author

Correspondence to V. G. Kon’kov.

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Conflict of interest. The authors declare that they have no conflicts of interest.

Ethical approval. The study was performed in accordance with the Directive of the Council of the European Community 2010/63/EEC, the decision of the Council of the Eurasian Economic Commission from November 3, 2016, no. 81 “On approval of the Rules of good laboratory practice in the Eurasian Economic Union in the field of circulation of medicines” and the order of the Ministry of Health of Russia no. 199 dated April 1, 2016 “On approval of the rules of good laboratory practice”. The animals were kept in accordance with SP 2.2.1.3218-14 “Sanitary and epidemiological requirements for the arrangement, equipment and maintenance of experimental biological clinics (vivariums)" dated August 29, 2014, No. 51.

Additional information

V. G. Kon’kov is a corresponding author: 125315 Russia, Moscow, Baltiiskaya ul., 8, e-mail: asbest321@gmail.com.

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Kon’kov, V.G., Kudrin, V.S., Narkevich, V.B. et al. The Effect of Noopept on the Content of Monoamines and Their Metabolites and Neurotransmitter Amino Acids in the Brain Structures of BALB/c and C57BL/6 Mice: A Comparative Study. Neurochem. J. 16, 161–167 (2022). https://doi.org/10.1134/S181971242202009X

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  • DOI: https://doi.org/10.1134/S181971242202009X

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