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Pre-wetting process with helium atmospheric pressure glow discharge for three-dimensional porous scaffold

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Abstract

Recently, three-dimensional polymer scaffolds were developed for tissue regeneration. Conventional pre-wetting processes require a lengthy processing time and have residue problems. In this study, a helium atmospheric pressure glow discharge (He-APGD) was employed as a pre-wetting process for porous poly-(L-lactide-co-ɛ-caprolactone) (PLCL) scaffold. The three minutes treated PLCL scaffold absorbed the culture media and contained grafted hydroxyl, carbonyl, and carboxyl groups. Moreover, it did not show cytotoxicity, did not require residual rinsing steps and showed a homogeneous cell distribution. The He-APGD treatment has a short processing time and promotes a homogenous cell distribution. Therefore, this pre-wetting process is expected to find many applications in the future.

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Authors and Affiliations

  1. Cellbiocontrol Laboratory, Department of Medical Engineering, Yonsei University College of Medicine, Seoul, 120-752, Korea

    Inho Han, Barbora Vagaska, Dae Hyung Lee, Bong Joo Park & Jong-Chul Park

  2. Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, 120-752, Korea

    Barbora Vagaska & Jong-Chul Park

  3. Department of Biomedical Engineering, College of Biomedical Science and Engineering, Inje University, Gyeongnam, 621-749, Korea

    Bong Joo Park, Seung-Woo Shin & Jeong Koo Kim

  4. Department of Industrial Pharmacy, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea

    Seung Jin Lee

Authors
  1. Inho Han
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  2. Barbora Vagaska
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  3. Dae Hyung Lee
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  4. Bong Joo Park
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  5. Seung-Woo Shin
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  6. Jeong Koo Kim
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  7. Seung Jin Lee
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  8. Jong-Chul Park
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Correspondence to Jong-Chul Park.

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Han, I., Vagaska, B., Lee, D.H. et al. Pre-wetting process with helium atmospheric pressure glow discharge for three-dimensional porous scaffold. Macromol. Res. 19, 711–715 (2011). https://doi.org/10.1007/s13233-011-0701-7

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  • DOI: https://doi.org/10.1007/s13233-011-0701-7

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