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Corpus callosum involvement and postoperative outcomes of patients with gliomas

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Abstract

Corpus callosum involvement is associated with poorer survival in high grade glioma (HGG), but the prognostic value in low grade glioma (LGG) is unclear. To determine the prognostic impact of corpus callosum involvement on progression free survival (PFS) and overall survival (OS) in HGG and LGG, the records of 233 glioma patients treated from 2008 to 2011 were retrospectively reviewed. Preoperative magnetic resonance (MR) images were used to identify corpus callosum involvement. Age, sex, preoperative Karnofsky performance scale, postoperative Eastern Cooperative Oncology Group (ECOG) score and extent of resection (EOR) were evaluated with respect to PFS and OS. The incidence of corpus callosum involvement was similar among HGG (14 %) and LGG (14.5 %). Univariate analysis revealed that PFS and OS were significantly shorter in both WHO grade II and grade IV glioma with corpus callosum involvement (both, p < 0.05). Multivariate analysis showed that grade II glioma with corpus callosum involvement have shorter PFS (p = 0.03), while EOR, instead of corpus callosum involvement (p = 0.16), was an independent factor associated with PFS in grade IV glioma (p < 0.05). Corpus callosum involvement was no longer significantly associated with OS after adjusting age, gender, EOR, preoperative and postoperative performance status (p = 0.16, 0.17 and 0.56 in grade II, III and IV gliomas, respectively). Corpus callosum involvement happened in both LGG and HGG, and is associated with lower EOR and higher postoperative ECOG score both in LGG and HGG. Corpus callosum involvement tends to be an independent prognostic factor for PFS in LGG, but not for OS in LGG or in HGG.

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Acknowledgments

Chang Gung Memorial Hospital Cancer Center. This work was supported by the Grants from Chang Gung Memorial Hospital (Nos. CMRPG3D0241, CORPG3C0041) and Ministry of Science and Technology, Taiwan (Nos. 102-2334-B-182A-068-MY3, 104-2325-B-182-001).

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Authors and Affiliations

  1. Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, No. 5, Fu Xing St., Gueishan Township, Taoyuan County, 333, Taiwan, ROC

    Ko-Ting Chen, Tai-Wei Erich Wu, Chi-Cheng Chuang, Yung-Hsin Hsu, Peng-Wei Hsu, Yin-Cheng Huang, Tzu-Kang Lin, Chen-Nen Chang, Shih-Tseng Lee, Chieh-Tsai Wu, Kuo-Chen Wei & Pin-Yuan Chen

  2. School of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC

    Chi-Cheng Chuang, Yung-Hsin Hsu, Peng-Wei Hsu, Yin-Cheng Huang, Tzu-Kang Lin, Chen-Nen Chang, Shih-Tseng Lee, Chieh-Tsai Wu, Kuo-Chen Wei & Pin-Yuan Chen

  3. Department of Radiation Oncology, Chang Gung Memorial Hospital at Linkou, Chang-Gung University, Taoyuan, Taiwan, ROC

    Chen-Kan Tseng, Chun-Chieh Wang & Ping-Ching Pai

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  1. Ko-Ting Chen
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  2. Tai-Wei Erich Wu
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  14. Kuo-Chen Wei
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  15. Pin-Yuan Chen
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Correspondence to Pin-Yuan Chen.

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Chen, KT., Wu, TW.E., Chuang, CC. et al. Corpus callosum involvement and postoperative outcomes of patients with gliomas. J Neurooncol 124, 207–214 (2015). https://doi.org/10.1007/s11060-015-1823-0

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  • DOI: https://doi.org/10.1007/s11060-015-1823-0

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