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Preparation and characterization of phospholipid complexes of naringenin for effective drug delivery

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Journal of Inclusion Phenomena and Macrocyclic Chemistry Aims and scope Submit manuscript

Abstract

Naringenin is a flavonoid specific to citrus fruits and possesses anti-inflammatory, anticarcinogenic, and antitumour effects. But due to a lower half-life and rapid clearance from the body, frequent administration of the molecule is required. To improve the bioavailability and prolong its duration in body system, its phospholipid complexes were prepared by a simple and reproducible method. Naringenin was complexed with phosphatidylcholine in equimolar ratio, in presence of dichloromethane. The prepared Phytosomes (naringenin–phospholipid complex) were evaluated for various physical parameters like FT-IR spectroscopy, Differential Scanning Calorimetry (DSC), X-ray powder diffractometry (XRPD), Solubility, Scanning Electron Microscopy (SEM) and the in vitro drug release study. These phospholipid complexes of naringenin were found to be irregular and disc shaped with rough surface in SEM. Drug content was found to be 91.7% (w/w). FTIR, 1H NMR, DSC and XRPD data confirmed the formation of phospholipid complex. Water solubility of naringenin improved from 43.83 to 79.31 μg/mL in the prepared complex. Unlike the free naringenin (which showed a total of only 27% drug release at the end of 10 h), naringenin complex showed 99.80% release at the end of 10 h of dissolution study. Thus it can be concluded that the phospholipid complex of naringenin may be of potential use for improving bioavailability.

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Acknowledgments

Authors acknowledge the grant provided by the Department of Science and Technology, Govt. of India for the research work. Authors are also thankful to LIPOID GmbH Germany for providing the gift sample of phosphatidylcholine for the research work. Facilities provided by the UGC-DAE Consortium for Scientific Research, Indore (M.P.) and Department of Chemistry, University of Delhi are thankfully acknowledged.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, H.N.B. Garhwal University, Srinagar (Garhwal), India

    Ajay Semalty & Mona Semalty

  2. Department of Chemistry, H.N.B. Garhwal University, Srinagar (Garhwal), India

    Devendra Singh & M. S. M. Rawat

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  1. Ajay Semalty
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  2. Mona Semalty
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  3. Devendra Singh
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  4. M. S. M. Rawat
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Correspondence to Ajay Semalty.

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Semalty, A., Semalty, M., Singh, D. et al. Preparation and characterization of phospholipid complexes of naringenin for effective drug delivery. J Incl Phenom Macrocycl Chem 67, 253–260 (2010). https://doi.org/10.1007/s10847-009-9705-8

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  • DOI: https://doi.org/10.1007/s10847-009-9705-8

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