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Impact of silicon-based quantum dots on the antioxidative system in white muscle of Carassius auratus gibelio

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Abstract

Silicon-based quantum dots were intraperitoneally injected in individuals of Carassius auratus gibelio. Their effects on white muscle were investigated by following their distribution and impact on the antioxidative system. The GSH level significantly increased after 1 and 3 days of exposure by, respectively, 85.3 and 25.4%. Seven days later, GSH levels were similar to control concentrations. MDA concentration rose after three days by 46.9% and remained at the same level after 7 days. Protein thiol levels significantly decreased by 6.7 and 8.1% after 3 and 7 days, whereas advanced oxidation protein products increased by 12.7, respectively, 28.1% in the same time intervals. The protein reactive carbonyl groups were raised only after the first day of exposure and returned to the control level later on. SOD specific activity increased up to 48% after 7 days, while CAT activity increased by 328, 176, and 26% after 1, 3, and 7 days of treatment. GST specific activity was up-regulated by 87, 18, and 9%, while GR activity increased by 68, 34, and 9%. G6PD activity was up-regulated by 12, 22, and 50%, whereas GPx activity raised by 75 and 109% compared to control after, respectively, 1, 3, and 7 days. Our results suggest that oxidative stress induced by silicon-based quantum dots was not strong enough to cause permanent damage in the white muscle of crucian carp.

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Acknowledgments

This study was financially supported by the National Research Council of Higher Education, Romania, grant number 127TE/2010 and Grant POSDRU 88/1.5/S/61150/2010 co-financed from European Social Fund by the Sectorial Operational Program for Development of Human Resources 2007–2010. The authors are grateful to COST CM1001/2010 Action for the opportunity to change ideas with experts in post-translational modifications of proteins. We also thank Prof. Radu Burlacu for his advice concerning statistical analysis.

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  1. Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independetei, 050095, Bucharest, Romania

    Loredana Stanca, Sorina Nicoleta Petrache, Mihaela Radu, Andreea Iren Serban, Maria Cristina Munteanu, Daniela Teodorescu, Andreea Cristina Staicu, Marieta Costache, Otilia Zarnescu & Anca Dinischiotu

  2. Department of Preclinical Sciences, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, 105 Splaiul Independetei, 050097, Bucharest, Romania

    Andreea Iren Serban

  3. Laser Department, National Institute of Laser, Plasma and Radiation Physics, 409 Atomistilor, 077125, Bucharest-Magurele, Romania

    Cornelia Sima & Constantin Grigoriu

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  1. Loredana Stanca
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Stanca, L., Petrache, S.N., Radu, M. et al. Impact of silicon-based quantum dots on the antioxidative system in white muscle of Carassius auratus gibelio . Fish Physiol Biochem 38, 963–975 (2012). https://doi.org/10.1007/s10695-011-9582-0

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