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Body mass index, diabetes, and triple-negative breast cancer prognosis

  • Epidemiology
  • Published:
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Abstract

Higher body mass index (BMI) and diabetes are associated with worse breast cancer prognosis. However, few studies have focused on triple-negative breast cancer (TNBC). The goal of this study is to examine this association in a cohort of patients with TNBC. We retrospectively reviewed 501 consecutive patients with TNBC seen at the Washington University Breast Oncology Clinic. Cox proportional hazard models were used to determine the relationship between BMI and diabetes at diagnosis with overall survival (OS) and disease free survival (DFS). Four hundred and forty-eight patients had BMI recorded and 71 patients had diabetes. The median age at diagnosis was 53 (23–98) years and follow-up was 40.1 months (IQR 25.2–62.9). Baseline BMI and diabetes were not associated with OS or DFS. OS hazard ratios (HRs) for patients who were overweight (BMI 25.0–29.99), with class I obesity (BMI 30–34.99), or BMI ≥35 were 1.22 (CI 0.78–1.91), 0.92 (CI 0.59–1.43), and 1.16 (CI 0.70–1.90), respectively. The HRs for DFS in patients who were overweight, with class I obesity, or BMI ≥35 were 1.01 (CI 0.65–1.56), 0.94 (CI 0.60–1.47), and 0.99 (CI 0.63–1.57), respectively. Similarly, the HRs for diabetics were 1.27 (CI 0.82–1.96) for OS and 0.98 (CI 0.64–1.51) for DFS. Obesity and diabetes did not significantly affect survival for patients with TNBC in this study.

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Acknowledgments

We would like to thank patients who participated in this study and physicians, nurses, and research coordinators at Washington University Breast Oncology Clinic for their care of these patients. The authors also wish to acknowledge the support of the Biostatistics Core, Siteman Cancer Center and National Cancer Institute Cancer Center Support Grant P30 CA091842.

Conflicts of Interest

All the authors of this manuscript have no conflicts of interest to disclose.

Author information

Authors and Affiliations

  1. Department of Biology, University of Virginia, Charlottesville, VA, USA

    Sarah Tait

  2. Division of Hospitalist Medicine, Barnes Jewish Hospital, Saint Louis, MO, USA

    Jose M. Pacheco

  3. Division of Medicine, John Cochran Veterans Hospital, Saint Louis, MO, USA

    Jose M. Pacheco

  4. Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA

    Feng Gao

  5. Section of Breast Oncology, Division of Oncology, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, P.O. Box 8056, St. Louis, MO, 63110, USA

    Caroline Bumb, Matthew James Ellis & Cynthia X. Ma

  6. Siteman Cancer Center, Saint Louis, MO, USA

    Feng Gao, Matthew James Ellis & Cynthia X. Ma

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  1. Sarah Tait
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Corresponding author

Correspondence to Jose M. Pacheco.

Additional information

This work was partly presented at the 2014 Annual Meeting of the American Society of Clinical Oncology, May 30–June 3, 2014, Chicago, IL, USA

S. Tait and J. M. Pacheco have contributed equally to this study.

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Tait, S., Pacheco, J.M., Gao, F. et al. Body mass index, diabetes, and triple-negative breast cancer prognosis. Breast Cancer Res Treat 146, 189–197 (2014). https://doi.org/10.1007/s10549-014-3002-y

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  • DOI: https://doi.org/10.1007/s10549-014-3002-y

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