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Divergent effects of insulin-like growth factor-1 receptor expression on prognosis of estrogen receptor positive versus triple negative invasive ductal breast carcinoma

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Abstract

The insulin-like growth factor type 1 receptor (IGF1R) is involved in progression of breast cancer and resistance to systemic treatment. Targeting IGF1R signaling may, therefore, be beneficial in systemic treatment. We report the effect of IGF1R expression on prognosis in invasive ductal breast carcinoma (IDC), the most common type of breast cancer. Immunohistochemistry was performed on tumor tissue of a consecutive cohort of 429 female patients treated for operable primary IDC. Associations between IGF1R expression with clinicopathological parameters, disease free survival (DFS) and breast cancer specific survival (BCSS) were evaluated by multivariate analyses focusing on ER-positive and triple negative IDC (TN-IDC). To enlarge the TN-IDCs cohort, we analyzed a combined dataset of 51 TN-IDC tumors from our series with 64 TN-IDCs with similar clinicopathological parameters. Patients with tumors expressing cytoplasmic IGF1R have a longer DFS and BCSS (DFS: HR 0.46, 95% CI 0.27–0.49, P = 0.005, BCSS: HR 0.38, 95% CI 0.19–0.74, P = 0.005). This effect was most prominent in ER-positive tumors. However, in a combined series of 105 TN-IDCs cytoplasmic IGF1R expression was associated with a shorter DFS (HR = 2.29, 95% CI 1.08–4.84, P = 0.03), also when combined in a multivariate model, including well-known prognostic factors (HR 2.06; 95% CI 0.95–4.47; P = 0.07). IGF1R expression in ER-positive IDC is strongly related to a favorable DFS and BCSS, but to a shorter DFS in TN-IDC tumors. This divergent effect of IGF1R expression in subgroups of IDC may affect selection of patients for IGF1R targeted therapy.

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Authors and Affiliations

  1. Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Hermien Hartog

  2. Department of Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    Bert van der Vegt

  3. Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

    H. Marike Boezen & Geertruida H. de Bock

  4. Division of Experimental Therapy, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Hugo M. Horlings, Bas Kreike & Abderrahim Ajouaou

  5. Department of Radiotherapy, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands

    Bas Kreike

  6. Department of Pathology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Jelle Wesseling

  7. Department of Pathology, Academic Medical Center, Amsterdam, The Netherlands

    Marc J. van de Vijver

  8. Department of Medical Oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands

    Winette T. A. van der Graaf

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  1. Hermien Hartog
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  2. Hugo M. Horlings
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  3. Bert van der Vegt
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  4. Bas Kreike
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  5. Abderrahim Ajouaou
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  6. Marc J. van de Vijver
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  7. H. Marike Boezen
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  8. Geertruida H. de Bock
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  9. Winette T. A. van der Graaf
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  10. Jelle Wesseling
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Correspondence to Jelle Wesseling.

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Hartog and Horlings contributed equally.

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Hartog, H., Horlings, H.M., van der Vegt, B. et al. Divergent effects of insulin-like growth factor-1 receptor expression on prognosis of estrogen receptor positive versus triple negative invasive ductal breast carcinoma. Breast Cancer Res Treat 129, 725–736 (2011). https://doi.org/10.1007/s10549-010-1256-6

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