Bulletin of Experimental Biology and Medicine

, Volume 140, Issue 4, pp 403–405

Lanthanum Potentiates GABA-Activated Currents in Rat Pyramidal Neurons of CA1 Hippocampal Field

  • A. A. Boldyreva
Biophysics and Biochemistry

DOI: 10.1007/s10517-005-0503-z

Cite this article as:
Boldyreva, A.A. Bull Exp Biol Med (2005) 140: 403. doi:10.1007/s10517-005-0503-z


In CA1 hippocampal pyramidal neurons, lanthanum ions increased the amplitude of GABA-activated currents and shifted the dose-dependence curve to the left, which attests to increased affinity of GABAA-receptors to GABA. The data made it possible to compare the sensitivity GABAA-receptors of pyramidal neurons and similar receptors of other cells to GABA and lanthanum.

Key Words

GABApyramidal neuronslanthanumpatch clamp

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • A. A. Boldyreva
    • 1
  1. 1.Brain Research InstituteRussian Academy of Medical SciencesMoscowRussia