Archivum Immunologiae et Therapiae Experimentalis

, Volume 64, Issue 6, pp 463–483

Transcription Factor NF-κB: An Update on Intervention Strategies

  • Arvind Panday
  • Maria Eugenia Inda
  • Prathyusha Bagam
  • Malaya K. Sahoo
  • Diana Osorio
  • Sanjay Batra
Review

DOI: 10.1007/s00005-016-0405-y

Cite this article as:
Panday, A., Inda, M.E., Bagam, P. et al. Arch. Immunol. Ther. Exp. (2016) 64: 463. doi:10.1007/s00005-016-0405-y

Abstract

The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic molecules that regulate the expression of more than 150 genes involved in a broad range of processes including inflammation, immunity, cell proliferation, differentiation, and survival. The chronic activation or dysregulation of NF-κB signaling is the central cause of pathogenesis in many disease conditions and, therefore, NF-κB is a major focus of therapeutic intervention. Because of this, understanding the relationship between NF-κB and the induction of various downstream signaling molecules is imperative. In this review, we provide an updated synopsis of the role of NF-κB in DNA repair and in various ailments including cardiovascular diseases, HIV infection, asthma, herpes simplex virus infection, chronic obstructive pulmonary disease, and cancer. Furthermore, we also discuss the specific targets for selective inhibitors and future therapeutic strategies.

Keywords

NF-κB Asthma COPD HIV HSV Cancer DNA damage 

Copyright information

© L. Hirszfeld Institute of Immunology and Experimental Therapy, Wroclaw, Poland 2016

Authors and Affiliations

  • Arvind Panday
    • 1
    • 2
  • Maria Eugenia Inda
    • 3
  • Prathyusha Bagam
    • 4
  • Malaya K. Sahoo
    • 5
  • Diana Osorio
    • 1
  • Sanjay Batra
    • 1
    • 4
  1. 1.Department of Pathobiological Sciences, School of Veterinary MedicineLouisiana State UniversityBaton RougeUSA
  2. 2.Department of Biological SciencesLouisiana State UniversityBaton RougeUSA
  3. 3.Departamento de Microbiología, CONICET, Facultad de Ciencias Bioquímicas y FarmacéuticasUniversidad Nacional RosarioSanta FeArgentina
  4. 4.Laboratory of Pulmonary Immunotoxicology, Environmental Toxicology PhD Program, 207 Health Research CenterSouthern University and A&M CollegeBaton RougeUSA
  5. 5.Department of PathologyStanford University School of MedicineStanfordUSA