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Abnormalities of T cells isolated from mediastinal lymph nodes and peripheral blood of patients with lung carcinoma: deficit in PHA-induced expression of HLA class II antigens and in autologous mixed lymphocyte reactions

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Summary

A reduced percentage of T cells isolated from mediastinal lymph nodes and peripheral blood of patients with lung carcinoma acquired HLA Class II antigens following in vitro stimulation with PHA. Furthermore T cells were functionally abnormal in autologous and allogeneic mixed lymphocyte reactions (MLR). The immunoregulatory properties of HLA Class II antigens and autologous MLRs suggest that these abnormalities may affect the interaction of the host's immune system with tumor cells.

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Authors and Affiliations

  1. Medical School University of Genova, ISMI - Immunologica Clinica, Italy

    F. Indiveri & A. Poggi

  2. Clinica Medica RR, Italy

    I. Pierri, S. Rogna, R. Romano & A. Tavano

  3. Semeiotica Chirurgica B, Viale Benedetto XV, I-16132, Genova, Italy

    G. Ratto & G. Motta

  4. Department of Microbiology and Immunology, New York Medical College, 10595, Valhalla, NY, USA

    S. Ferrone

Authors
  1. F. Indiveri
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  2. I. Pierri
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  3. S. Rogna
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  4. A. Poggi
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  5. R. Romano
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  6. A. Tavano
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  7. G. Ratto
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  8. G. Motta
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  9. S. Ferrone
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Indiveri, F., Pierri, I., Rogna, S. et al. Abnormalities of T cells isolated from mediastinal lymph nodes and peripheral blood of patients with lung carcinoma: deficit in PHA-induced expression of HLA class II antigens and in autologous mixed lymphocyte reactions. Cancer Immunol Immunother 22, 232–235 (1986). https://doi.org/10.1007/BF00200038

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  • DOI: https://doi.org/10.1007/BF00200038

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