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Changes of the Serum Cytokine Contents in Broilers Fed on Diets Supplemented with Nickel Chloride

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Abstract

Cytokines are immunoregulatory proteins which play an important role in the immune system. The purpose of this study was to examine the serum cytokine contents including interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), interferon gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α) induced by dietary nickel chloride in broilers by enzyme-linked immunospecific assay. A total of 240 one-day-old avian broilers were divided into four groups and fed on a corn–soybean basal diet as control diet or the same basal diet supplemented with 300, 600, and 900 mg/kg of nickel chloride. During the experimental period of 42 days, the results showed that the serum IL-2, IL-4, IL-6, IL-10, IFN-γ and TNF-α contents were lower (p < 0.05 or p < 0.01) in the 300, 600, 900 mg/kg groups than those in the control group. It was concluded that dietary nickel chloride in the range of 300 to 900 mg/kg could reduce the serum cytokine contents, which could finally impact the immune function in broilers.

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Acknowledgments

The study was supported by the program for Changjiang scholars and innovative research team in university (IRT 0848) and the Education Department and Scientific department of Sichuan Province (09ZZ017).

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Authors and Affiliations

  1. Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Ya’an, 625014, China

    Bangyuan Wu, Hengmin Cui, Xi Peng, Jing Fang, Zhicai Zuo, Jianying Huang, Qin Luo, Yubing Deng, Hesong Wang & Juan Liu

  2. College of Veterinary Medicine, Sichuan Agricultural University, Ya’an, Sichuan, China, 625014

    Hengmin Cui

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  1. Bangyuan Wu
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Correspondence to Hengmin Cui.

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Wu, B., Cui, H., Peng, X. et al. Changes of the Serum Cytokine Contents in Broilers Fed on Diets Supplemented with Nickel Chloride. Biol Trace Elem Res 151, 234–239 (2013). https://doi.org/10.1007/s12011-012-9554-y

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  • DOI: https://doi.org/10.1007/s12011-012-9554-y

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