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Nickel Exposure and its Effects

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Abstract

The aim of the study was to determine the nickel concentrations of soil and plant specimens taken from a rural area exposed to cement factory emissions and also to determine the blood concentrations and sensitivity conditions observed in humans residing in this rural area. The study was carried out in Çukurhisar, a town in Eskişehir-Turkey, between May 2000 and March 2001. Beside the 108 soil (36 for control) and plant specimens, which were taken from 8 directions from the cement factory, blood samples of the individuals residing in this area were taken from 258 subjects (258 for control) following a physical examination, and patch tests were also applied. The nickel concentrations of the soil and plant specimens taken from different places in different directions of the factory were higher than in the control areas. The physical examination of subjects did not reveal results different from those of the control group except for the diagnosis of contact dermatitis. The analyses of venous blood samples showed that nickel concentrations were found to be within the reference values given for both groups, but higher in the subjects (p<0.001). According to the results of patch tests, sensitivity to nickel was found to be more frequent for the subject group than the control group (p<0.05). According to these results, clinical tools revealed no toxic effects for the subjects, except contact dermatitis. However, sensitivity to patch tests showed that this subject group has been affected compared to the control group and that this effect increased with age.

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Authors and Affiliations

  1. Art and Science Faculty Department of Chemistry, Osmangazi University, Eskisehir, Turkey

    Temir A. Demir, Asiye Berber & Tamer Akar

  2. Medical Faculty Department of Public Health, Osmangazi University, Eskisehir, Turkey

    Burhanettin Işıklı & Cemalettin Kalyoncu

  3. Medical Faculty Department ofDermatology, Osmangazi University, Eskisehir, Turkey

    Selim M. Ürer

  4. Art and Science Faculty Department of Biology, Osmangazi University, Eskisehir, Turkey

    Mediha Canbek

Authors
  1. Temir A. Demir
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  2. Burhanettin Işıklı
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  3. Selim M. Ürer
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  4. Asiye Berber
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  5. Tamer Akar
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  6. Mediha Canbek
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  7. Cemalettin Kalyoncu
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Correspondence to Temir A. Demir.

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Published online December 2004

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Demir, T.A., Işıklı, B., Ürer, S.M. et al. Nickel Exposure and its Effects. Biometals 18, 7–13 (2005). https://doi.org/10.1007/s10534-004-1209-9

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  • DOI: https://doi.org/10.1007/s10534-004-1209-9

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