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Contrast-Induced Acute Kidney Injury: The At-Risk Patient and Protective Measures

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Abstract

Contrast-induced acute kidney injury (CI-AKI) is a major complication following radiocontrast procedures. In this review, we characterize the recent literature on CI-AKI, risk factors, prevention, biomarkers, and new technologies. The premise of CI-AKI prophylaxis should focus on implementing mandatory standing orders before and after cardiac catheterization for hydration with normal saline or sodium bicarbonate and use of high-dose (1200-mg) N-acetylcysteine. Contrast agents may play a role in preventing CI-AKI. Implement catheter-laboratory technology and awareness to limit the amount of contrast dye used for any patient.

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Papers of particular interest, published recently, have been highlighted as: • Of importance

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Acknowledgment

Dr. Jeremiah R. Brown is supported by the Agency for Healthcare Research and Quality, grant number K01 HS018443. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Agency for Healthcare Research and Quality.

Disclosures

Dr. Craig A. Thompson is a consultant for Bridgepoint Medical and Abbott Vascular.

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Authors and Affiliations

  1. Invasive Cardiology and Vascular Medicine, Yale University School of Medicine, PO Box 208017, 333 Cedar Street, Fitkin 3, New Haven, CT, 06520-8017, USA

    Craig A. Thompson

  2. The Dartmouth Institute for Health Policy and Clinical Practice, Section of Cardiology, Dartmouth Medical School, Hanover, NH, USA

    Jeremiah R. Brown

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  1. Jeremiah R. Brown
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  2. Craig A. Thompson
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Correspondence to Craig A. Thompson.

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Brown, J.R., Thompson, C.A. Contrast-Induced Acute Kidney Injury: The At-Risk Patient and Protective Measures. Curr Cardiol Rep 12, 440–445 (2010). https://doi.org/10.1007/s11886-010-0129-2

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  • DOI: https://doi.org/10.1007/s11886-010-0129-2

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