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Non-invasive Near Infrared Fluorescence Imaging of CdHgTe Quantum Dots in Mouse Model

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Abstract

Near infrared CdHgTe quantum dots (QDs) acted as biomarker for in vivo imaging were synthesized in aqueous solution. The size and the fluorescence wavelength of the synthesized quantum dots can be arbitrary manipulated by using different refluxing time. In particular, the fluorescence wavelength was extended to near infrared range (700∼900 nm), which make the in vivo imaging possible. Meanwhile, the characteristics, such as morphology, size, spectra, stability and toxicity were investigated. The dynamic bio-distribution, clearance from blood, liver and intestine in living animal were in vivo monitored by a NIR imaging system. The circulation of CdHgTe QDs in living mice was addressed semi-quantitatively according to the changes of fluorescence intensity. The high stability as well as high fluorescence intensity makes QDs particular interested candidates for in vivo imaging studies.

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Acknowledgments

The authors are grateful to Natural Science Foundation Committee of China (NSFC30672015, NSFC03030103), the Ministry of Education of China and China Pharmaceutical University for their financial supports.

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Authors and Affiliations

  1. Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, 24 Shennong Road, Nanjing, 210009, People’s Republic of China

    Haiyan Chen, Jian Zhang & Yueqing Gu

  2. Department of Analytical Chemistry, School of Basic Science, China Pharmaceutical University, 24 Shennong Road, Nanjing, 210009, People’s Republic of China

    Haiyan Chen, Yunqing Wang & Yuzhu Hu

  3. Department of Pharmacy, School of Pharmaceutical Science, China Pharmaceutical University, 24 Shennong Road, Nanjing, 210009, People’s Republic of China

    Jing Xu & Jinzi Ji

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  1. Haiyan Chen
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  2. Yunqing Wang
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  5. Jian Zhang
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Correspondence to Yueqing Gu.

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Chen, H., Wang, Y., Xu, J. et al. Non-invasive Near Infrared Fluorescence Imaging of CdHgTe Quantum Dots in Mouse Model. J Fluoresc 18, 801–811 (2008). https://doi.org/10.1007/s10895-007-0307-9

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  • DOI: https://doi.org/10.1007/s10895-007-0307-9

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