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Design and In Vitro Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels

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Abstract

The purpose of this study was to design and investigate the transdermal controlled release cubic phase gels containing capsaicin using glycerol monooleate (MO), propylene glycol (1,2-propanediol, PG), and water. Three types of cubic phase gels were designed based on the ternary phase diagram of the MO–PG–water system, and their internal structures were confirmed by polarizing light microscopy (PLM) and small-angle X-ray scattering (SAXS). Release results showed the cubic phase gels could provide a sustained system for capsaicin, while the initial water content in the gels was the major factor affecting the release rate. Release kinetics was determined to fit Higuchi’s square-root equation indicating that the release was under diffusion control. The calculated diffusion exponent showed the release from cubic phase gels was anomalous transport. The unique structure of the cubic phases, capsaicin distributed in the lipid bilayers, and cubic phase gel swelling contributed to the release mechanism. The cubic phase gel may be an interesting application for transdermal delivery system of capsaicin in alleviating the post-incision pain.

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ACKNOWLEDGEMENTS

The authors are grateful to Danisco Company, Denmark, for the generous gift samples of MO. We thank the National Natural Science Foundation of China for the financial support (No 81001643/H2806). This work was also supported in part by the Ministry of Science and Technology of Dongguan (NO 2008108101064).

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Authors and Affiliations

  1. School of Pharmaceutical Sciences, Sun Yat-Sen University, University Town, Guangzhou, 510006, China

    Xinsheng Peng, Xinguo Wen, Xin Pan, Rongchang Wang, Bao Chen & Chuanbin Wu

  2. School of Pharmaceutical Sciences, Guangdong Medical College, Dongguan, 523808, China

    Xinsheng Peng

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  1. Xinsheng Peng
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Correspondence to Chuanbin Wu.

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Peng, X., Wen, X., Pan, X. et al. Design and In Vitro Evaluation of Capsaicin Transdermal Controlled Release Cubic Phase Gels. AAPS PharmSciTech 11, 1405–1410 (2010). https://doi.org/10.1208/s12249-010-9481-1

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