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Optimization of capsaicin microemulgel: a comprehensive in vitro evaluation and pseudo ternary diagram

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A Correction to this article was published on 15 February 2024

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Abstract

Aim of the current study was to prepare and estimate capsaicin loaded microemulgel (CaP-ME) for the treatment of inflammation. The preparation of CaP-ME was based on the pseudo ternary phase diagram by the phase titration method using various oils such as clove oil, cinnamon oil, turpent oil. To the CaP-ME, different combination of gelling agents was incorporated. CaP-ME was prepared by incorporating different gelling agent such as aerosil and chitosan in to a CaP-MEs. Various preparations were assessed for pH, physical appearance, spreadability, in vitro release and particle size (PS), etc. The results obtained from the preparation of CaP-ME exhibited globule size of 31.6 ± 1.11 nm, polydisperse index (0.441 ± 0.02), % transmittance, and drug content (95.5 ± 8.16%) were within in the range. From the performed pseudo ternary phase diagrams using various oils, 3 pseudo ternary phase diagram was selected based on the area of ME for the further formulation of MEs. Three MEs (F1, F2, F3) were prepared and the F3 shown the better results in all the parameters. The chitosan (G1)-based CaP-ME (F3) gel had a good transparency, better spreadability, extrudability, pH and in vitro release (94.76 ± 5.09%). Hence, it was concluded that turpentine oil is the best oil phase for the preparation of CaP-MEs when compared with other oils like clove oil and cinnamon oil and chitosan-based gel exhibits their efficient topical delivery.

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Acknowledgements

This research was funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R110), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia, and by the Researchers Supporting program, AlMaarefa University, Riyadh, Saudi Arabia. Also, this study is supported via funding from Prince Sattam bin Abdulaziz University project number (PSAU/2023/R/1444). The authors extend their appreciation to the Deanship of Scientific Research at King Khalid University for funding this work through large group Research Project under a grant number (R.G.P.2/66/44).

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Authors and Affiliations

  1. Faculty of Pharmacy & BioMedical Sciences, MAHSA University, Bandar Saujana Putra, 42610, Jenjarom, Selangor, Malaysia

    Jamal Moideen Muthu Mohamed

  2. Department of Chemistry, College of Sciences, Jazan University, P. O box no. 114, 45142, Jazan, Saudi Arabia

    Aayesha Nasreen

  3. College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Al-Ahsa, Riyadh, Saudi Arabia

    Mohammed Ahmad Al Mohaini

  4. King Abdullah International Medical Research Center, Al-Ahsa, Riyadh, Saudi Arabia

    Mohammed Ahmad Al Mohaini

  5. Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, 11597, Riyadh, Saudi Arabia

    Mohamed El-Sherbiny & Mamdouh Basheir Eldesoqui

  6. Department of Anatomy, Faculty of Medicine, Mansoura, Egypt

    Mohamed El-Sherbiny & Mamdouh Basheir Eldesoqui

  7. Department of Basic Medical Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia

    Amal Fahmy Dawood

  8. Department of Clinical Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, 11597, Riyadh, Saudi Arabia

    Moneer AlMadani

  9. Department of Nursing, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia

    Ateya Megahed Ibrahim

  10. Department of Family and Community Health Nursing, Faculty of Nursing, Port Said University, Port Said, Egypt

    Ateya Megahed Ibrahim

  11. Biology Department, College of Science, King Khalid University, 61413, Abha, Saudi Arabia

    Ahmed A. El-Mansi

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  1. Jamal Moideen Muthu Mohamed
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  2. Aayesha Nasreen
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  3. Mohammed Ahmad Al Mohaini
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Correspondence to Jamal Moideen Muthu Mohamed.

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Mohamed, J.M.M., Nasreen, A., Al Mohaini, M.A. et al. Optimization of capsaicin microemulgel: a comprehensive in vitro evaluation and pseudo ternary diagram. Chem. Pap. 78, 2155–2164 (2024). https://doi.org/10.1007/s11696-023-03216-1

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