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MICROmanagement of Runx2 Function in Skeletal Cells

  • MicroRNAs in Skeletal Development (A Delany, Section Editor)
  • Published:
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Abstract

Purpose of Review

Precise and temporal expression of Runx2 and its regulatory transcriptional network is a key determinant for the intricate cellular and developmental processes in adult bone tissue formation. This review analyzes how microRNA functions to regulate this network, and how dysregulation results in bone disorders.

Recent Findings

Similar to other biologic processes, microRNA (miRNA/miR) regulation is undeniably indispensable to bone synthesis and maintenance. There exists a miRNA–RUNX2 network where RUNX2 regulates the transcription of miRs or is post-transcriptionally regulated by a class of miRs, forming a variety of miR-RUNX2 regulatory pathways which regulate osteogenesis.

Summary

The current review provides insights to understand transcriptional–post-transcriptional regulatory network governed by Runx2 and osteogenic miRs, and is based largely from in vitro and in vivo studies. When taken together, this article discusses a new regulatory layer of bone tissue-specific gene expression by RUNX2 influenced via miRNA.

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Acknowledgments

We thank the members of RNA Biology and Epigenetics laboratory, School of Dentistry, UAB, for assistance with critical comments, valuable suggestions, and support. We are thankful to the National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIH/NIAMS) under Award Number 1R01AR069578 supported research for this publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Funding

We are thankful to the National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIH/NIAMS) under Award Number 1R01AR069578 supported research for this publication.

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  1. RNA Biology and Epigenetics Laboratory, Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Alabama at Birmingham, Birmingham, AL, 35233, USA

    Benjamin J. Wildman, Tanner C. Godfrey, Mohammad Rehan, Yuechuan Chen, Lubana H. Afreen & Quamarul Hassan

  2. Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Alabama at Birmingham, 1919 7th Avenue South, Birmingham, AL, 35233, USA

    Quamarul Hassan

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Benjamin J. Wildman, Tanner C. Godfrey, Mohammad Rehan, Yuechuan Chen, Lubana H. Afreen, and Quamarul Hassan each declare that they have no conflicts of interest with the contents of this article.

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Wildman, B.J., Godfrey, T.C., Rehan, M. et al. MICROmanagement of Runx2 Function in Skeletal Cells. Curr Mol Bio Rep 5, 55–64 (2019). https://doi.org/10.1007/s40610-019-0115-4

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