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Association of fat mass and obesity-associated (FTO) gene polymorphisms with non-communicable diseases (NCDs) in the Iranian population: A systematic review of observational studies

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Abstract

Background

Single nucleotide polymorphisms have been implicated in various diseases, most notably non-communicable diseases (NCDs). The aim of this study was to review available evidence regarding associations between FTO polymorphisms and NCDs in the Iranian population.

Methods

A comprehensive search was conducted through PubMed/Medline and Scopus databases up to December 2021, as well as reference lists of pertinent articles and key journals. All observational studies that examined the association between FTO gene polymorphisms and NCDs in the Iranian population were included. There was no limitation on the publication year. The Newcastle–Ottawa Scale (NOS) was used to assess the study's quality.

Results

The initial search yielded 95 studies, of which 30 studies were included in the current systematic review. The underlying disorders were obesity, type 2 diabetes, breast and colorectal cancers, depression, and metabolic syndrome. These studies found an association between FTO gene polymorphisms and obesity in the Iranian population, but the relationship with other NCDs was debatable. Even though, other diseases such as diabetes and metabolic syndrome, which are closely related to obesity, may also be associated with FTO gene polymorphisms.

Conclusion

FTO gene polymorphism appears to play a role in the occurrence of NCDs. Some of the study results may be misleading due to ethnic differences and the effect of other genetic factors on disease onset, which needs to be investigated further. Finally, FTO gene polymorphisms can be studied as a preventive or therapeutic target.

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Data availability

All data generated in this study are supported by the published articles in PubMed/Medline and Scopus databases, and all data generated are included in this published article.

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Funding

This study was funded by the Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran (Number: 1400–02-105–1164).

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Authors and Affiliations

  1. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Zahra Hoseini Tavassol, Seyed Mohammad Mousavi, Bahareh Molaei, Hanieh-Sadat Ejtahed, Kazem Khalagi, Shima Ghannadi & Shirin Hasani-Ranjbar

  2. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

    Seyed Mohammad Mousavi

  3. Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institutes, Tehran University of Medical Sciences, Tehran, Iran

    Fatemeh Bandarian

  4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Hanieh-Sadat Ejtahed & Bagher Larijani

  5. Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

    Kazem Khalagi

  6. Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran

    Shima Ghannadi

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  1. Zahra Hoseini Tavassol
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  2. Seyed Mohammad Mousavi
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  3. Bahareh Molaei
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  7. Shima Ghannadi
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  9. Shirin Hasani-Ranjbar
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Contributions

ZHT: Investigation, conceptualization, designing, writing – original draft. SMM: Investigation, designing, writing – review & editing. BM and FB: Investigation, writing – review & editing. SHR: Conceptualization, designing, project administration, supervision, writing – review & editing. HSE, KK, SG and BL: Conceptualization, writing – review & editing. All authors reviewed and approved the final manuscript.

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Correspondence to Shirin Hasani-Ranjbar.

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Hoseini Tavassol, Z., Mousavi, S.M., Molaei, B. et al. Association of fat mass and obesity-associated (FTO) gene polymorphisms with non-communicable diseases (NCDs) in the Iranian population: A systematic review of observational studies. J Diabetes Metab Disord 21, 1975–1989 (2022). https://doi.org/10.1007/s40200-022-01139-4

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