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A Monte Carlo study of pinhole collimated Cerenkov luminescence imaging integrated with radionuclide treatment

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Abstract

Cerenkov luminescence imaging (CLI) is an emerging optical imaging technique, which has been widely investigated for biological imaging. In this study, we proposed to integrate the CLI technique with the radionuclide treatment as a “see-and-treat” approach, and evaluated the performance of the pinhole collimator-based CLI technique. The detection of Cerenkov luminescence during radionuclide therapy was simulated using the Monte Carlo technique for breast cancer treatment as an example. Our results show that with the pinhole collimator-based configuration, the location, size and shape of the tumors can be clearly visualized on the Cerenkov luminescence images of the breast phantom. In addition, the CLI of multiple tumors can reflect the relative density of radioactivity among tumors, indicating that the intensity of Cerenkov luminescence is independent of the size and shape of a tumor. The current study has demonstrated the high-quality performance of the pinhole collimator-based CLI in breast tumor imaging for the “see-and-treat” multi-modality treatment.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 11805100), and the National Key Research and Development Program (Grant No. 2016YFE0103600 and No. 2017YFC0107700).

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Author notes

  1. Changran Geng and Yao Ai contributed equally to this work.

Authors and Affiliations

  1. Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, China

    Changran Geng, Yao Ai, Xiaobin Tang, Diyun Shu & Chunhui Gong

  2. Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Nanjing, 210016, China

    Changran Geng, Yao Ai, Xiaobin Tang, Diyun Shu & Chunhui Gong

  3. Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Fada Guan

Authors
  1. Changran Geng
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  2. Yao Ai
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  3. Xiaobin Tang
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  4. Diyun Shu
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  5. Chunhui Gong
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Correspondence to Xiaobin Tang.

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Geng, C., Ai, Y., Tang, X. et al. A Monte Carlo study of pinhole collimated Cerenkov luminescence imaging integrated with radionuclide treatment. Australas Phys Eng Sci Med 42, 481–487 (2019). https://doi.org/10.1007/s13246-019-00744-7

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  • DOI: https://doi.org/10.1007/s13246-019-00744-7

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