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Measurement of dose in radionuclide therapy by using Cerenkov radiation

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Abstract

This work aims to determine the relationship between Cerenkov photon emission and radiation dose from internal radionuclide irradiation. Water and thyroid phantoms were used to simulate the distribution of Cerenkov photon emission and dose deposition through Monte Carlo method. The relationship between Cerenkov photon emission and dose deposition was quantitatively analyzed. A neck phantom was also used to verify Cerenkov photon detection for thyroid radionuclide therapy. Results show that Cerenkov photon emission and dose deposition exhibit the same distribution pattern in water phantom, and this relative distribution relationship also existed in the thyroid phantom. Moreover, Cerenkov photon emission exhibits a specific quantitative relation to dose deposition. For thyroid radionuclide therapy, only a part of Cerenkov photon produced by thyroid could penetrate the body for detection; therefore, the use of Cerenkov radiation for measurement of radionuclide therapy dose may be more suitable for superficial tumors. This study demonstrated that Cerenkov radiation has the potential to be used for measuring radiation dose for radionuclide therapy.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant No. 11475087), the National Key Research and Development Program (Grant No. 2016YFE0103600), the Foundation of Graduate Innovation Center in NUAA (Grant Nos. kfjj20160610, kfjj20170617), and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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Authors and Affiliations

  1. Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, 29 Yudao St., Nanjing, 210016, China

    Yao Ai, Xiaobin Tang, Diyun Shu, Wencheng Shao, Chunhui Gong, Changran Geng, Xudong Zhang & Haiyan Yu

  2. Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 29 Yudao St., Nanjing, 210016, China

    Xiaobin Tang & Changran Geng

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  1. Yao Ai
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  2. Xiaobin Tang
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  3. Diyun Shu
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  4. Wencheng Shao
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  5. Chunhui Gong
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  7. Xudong Zhang
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Correspondence to Xiaobin Tang.

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Ai, Y., Tang, X., Shu, D. et al. Measurement of dose in radionuclide therapy by using Cerenkov radiation. Australas Phys Eng Sci Med 40, 695–705 (2017). https://doi.org/10.1007/s13246-017-0579-6

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  • DOI: https://doi.org/10.1007/s13246-017-0579-6

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