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Cowden Syndrome Detected by FDG PET/CT in an Endometrial Cancer Patient

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Abstract

Cowden syndrome (CS) is a rare autosomal dominant disorder characterized by multiple hamartomas in various tissues and cancers (breast, thyroid, and endometrium). We report CS of the esophagus and gastrointestinal tract that was incidentally detected by positron emission tomography/computed tomography (PET/CT) at postoperative surveillance in an endometrial cancer patient. PET/CT showed mildly increased FDG uptake along the entire esophagus and stomach. Upper GI endoscopy and histologic examination revealed glycogenic acanthosis of the esophagus and several hundred gastric polyps. In our case, increased FDG uptake of the esophageal wall contributed to the diagnosis of CS.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Eulji University Hospital, 96 Dunsanseo-ro, Seo-gu, Daejeon, 35233, Republic of Korea

    Yun Hee Kang

  2. Department of Pathology, Eulji University Hospital, 96 Dunsanseo-ro, Seo-gu, Daejeon, 35233, Republic of Korea

    Hye Kyung Lee

  3. Department of Radiology, The Catholic University of Korea, Daejeon Saint Mary’s Hospital, 64, Daeheung-ro, Jung-gu, Daejeon, 34943, Republic of Korea

    Geon Park

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  1. Yun Hee Kang
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  2. Hye Kyung Lee
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  3. Geon Park
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Correspondence to Geon Park.

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Conflict of Interest

Yun Hee Kang, Hye Kyung Lee, and Geon Park declare that they have no conflict of interest.

Ethical Statement

The study was approved by an institutional review board.

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Kang, Y.H., Lee, H.K. & Park, G. Cowden Syndrome Detected by FDG PET/CT in an Endometrial Cancer Patient. Nucl Med Mol Imaging 50, 255–257 (2016). https://doi.org/10.1007/s13139-016-0427-8

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  • DOI: https://doi.org/10.1007/s13139-016-0427-8

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