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The potential usefulness of 18F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults

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Abstract

Objective

The aim of this study was to evaluate the potential usefulness of 18F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults.

Methods

614 subjects were enrolled in this retrospective study. They underwent both 18F-FDG PET/CT and colonoscopy in the same day as part of a cancer-screening program. Small focal FDG accumulation along the colorectum on 18F-FDG PET/CT images were compared with colonoscopy findings. Size of lesion was measured on colonoscopy and histology was determined by biopsy or polypectomy.

Results

In 614 18F-FDG PET/CT images, 27 foci of FDG uptakes were observed in the colorectal area in 25 subjects. The overall sensitivity and specificity of 18F-FDG PET/CT were 5.6 and 96.8 %, respectively, but sensitivity to detect lesions larger than or equal to 1 cm was 25.8 %. On the ROC analysis, the optimal cut-off value for differentiating premalignant and malignant lesions from other benign conditions was 5.0 (sensitivity = 50 %, specificity = 88 %, AUC = 0.643).

Conclusions

Colonoscopic evaluation could be recommended by presence of focal colonic FDG uptake on 18F-FDG PET/CT, especially when SUVmax is over 5.

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Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, Soonchunhyang University Hospital, 657, Hannam-dong, Yongsan-gu, Seoul, 140-743, South Korea

    Jae Pil Hwang

  2. Molecular Imaging Research Center, Korea Institute of Radiological and Medical Sciences, 75 Nowon-gil, Gongneung-dong, Nowon-gu, Seoul, 139-706, Korea

    Sang-Keun Woo

  3. Department of Nuclear Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108, Pyung-Dong, Jongno-gu, Seoul, 110-746, South Korea

    Sang Yun Yoon & Su Young Jeong

Authors
  1. Jae Pil Hwang
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  2. Sang-Keun Woo
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  3. Sang Yun Yoon
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  4. Su Young Jeong
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Corresponding author

Correspondence to Su Young Jeong.

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Hwang, J.P., Woo, SK., Yoon, S.Y. et al. The potential usefulness of 18F-FDG PET/CT for detecting colorectal carcinoma and adenoma in asymptomatic adults. Ann Nucl Med 29, 157–163 (2015). https://doi.org/10.1007/s12149-014-0922-x

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  • DOI: https://doi.org/10.1007/s12149-014-0922-x

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