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Synthetic Biology Perspectives of Microbial Enzymes and Their Innovative Applications

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Abstract

Microbial enzymes are high in demand and there is focus on their efficient, cost effective and eco-friendly production. The relevant microbial enzymes for respective industries needs to be identified but the conventional technologies don’t have much edge over it. So, there is more attention towards high throughput methods for production of efficient enzymes. The enzymes produced by microbes need to be modified to bear the extreme conditions of the industries in order to get prolific outcomes and here the synthetic biology tools may be augmented to modify such microbes and enzymes. These tools are applied to synthesize novel and efficient enzymes. Use of computational tools for enzyme modification has provided new avenues for faster and specific modification of enzymes in a shorter time period. This review focuses on few important enzymes and their modification through synthetic biology tools including genetic modification, nanotechnology, post translational modification.

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Acknowledgements

The author acknowledges the help by Mr. Mandeep for the formatting of the manuscript. PS acknowledges the Department of Microbiology, Barkatullah University, Bhopal, India for their infrastructural support for D.Sc. Work. The infrastructural support from Department of Science and Technology, New Delhi, Govt. of India, through FIST Grant (Grant No. 1196 SR/FST/LS-I/2017/4) and Department of Biotechnology, Government of India (Grant No. BT/PR27437/BCE/8/1433/2018) is duly acknowledged.

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  1. Enzyme Technology and Protein Bioinformatics Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, 124001, India

    Pratyoosh Shukla

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Shukla, P. Synthetic Biology Perspectives of Microbial Enzymes and Their Innovative Applications. Indian J Microbiol 59, 401–409 (2019). https://doi.org/10.1007/s12088-019-00819-9

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