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Mast Cell Interactions and Crosstalk in Regulating Allergic Inflammation

  • Basic and Applied Science (I Lewkowich, Section Editor)
  • Published:
Current Allergy and Asthma Reports Aims and scope Submit manuscript

Abstract

Purpose of Review

This review summarizes recent findings on mast cell biology with a focus on IgE-independent roles of mast cells in regulating allergic responses.

Recent Findings

Recent studies have described novel mast cell-derived molecules, both secreted and membrane-bound, that facilitate cross-talk with a variety of immune effector cells to mediate type 2 inflammatory responses.

Summary

Mast cells are complex and dynamic cells that are persistent in allergy and are capable of providing signals that lead to the initiation and persistence of allergic mechanisms.

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Acknowledgements

The authors would like to thank Ms. Jacqueline Schaffer for her artistic work included in this review.

Funding

NIH Grant: R01 AI076456.

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Authors and Affiliations

  1. Division of Allergy-Immunology, Northwestern University Feinberg School of Medicine, 240 E. Huron St, Chicago, IL, 60611, USA

    Tania E. Velez, Paul J. Bryce & Kathryn E. Hulse

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  1. Tania E. Velez
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  2. Paul J. Bryce
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  3. Kathryn E. Hulse
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Correspondence to Kathryn E. Hulse.

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Velez, T.E., Bryce, P.J. & Hulse, K.E. Mast Cell Interactions and Crosstalk in Regulating Allergic Inflammation. Curr Allergy Asthma Rep 18, 30 (2018). https://doi.org/10.1007/s11882-018-0786-6

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