Abstract
Objective
To observe the clinical efficacy of Tuina (Chinese therapeutic massage) plus oxiracetam in treating mild vascular dementia (VD) and seek its underlying mechanism.
Methods
Ninety-six patients with mild VD were randomized into an observation group and a control group, with 47 cases in the observation group and 49 cases in the control group. The control group received oral oxiracetam capsules for treatment, and the observation group was given additional Tuina treatment. Before and after treatment, the mini-mental state examination (MMSE) was adopted to assess the patient’s cognitive function; the activities of daily living (ADL) scale was used to evaluate their ability to conduct daily activities; changes in the serum inflammatory factors and oxidative stress indicators were also detected.
Results
After treatment, the serum content of malondialdehyde (MDA) decreased in both groups (P<0.05) and was lower in the observation group than in the control group (P<0.05); the serum contents of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) increased in both groups (P<0.05) and were higher in the observation group than in the control group (P<0.05); the serum contents of interleukin (IL)-1, tumor necrosis factor (TNF)-α, IL-6, and IL-8 declined in both groups (P<0.05) and were lower in the observation group than in the control group (P<0.05). After the intervention, the levels of systolic velocity (Vs) and mean velocity (Vm) of the middle cerebral artery elevated, and the pulsatility index (PI) dropped in patients in the two groups, showing significant intra-group differences (P<0.05); the levels of Vs and Vm in the observation group were higher than those in the control group, and the PI was lower in the observation group than in the control group, showing significant between-group differences (P<0.05). The MMSE and ADL scores increased in both groups after the intervention (P<0.05) and were higher in the observation group than in the control group (P<0.05).
Conclusion
In the treatment of mild VD, Tuina plus oxiracetam can improve the cerebral blood supply, ADL, and cognitive function; the mechanism may be associated with the reduction of oxidative stress damages and inflammatory reactions.
摘要
目的
观察推拿联合奥拉西坦治疗轻度血管性痴呆(VD)的临床疗效并探索其潜在机制。
方法
将96例轻度血 管性痴呆患者随机分为观察组和对照组, 观察组47例, 对照组49例。对照组给予口服奥拉西坦胶囊治疗; 观察组在对 照组的基础上加用推拿治疗。治疗前后使用简易智能精神状态检查量表(MMSE)评价患者认知能力, 使用日常生活活 动(ADL)量表评价患者日常生活能力, 并监测血清炎性因子及氧化应激指标的变化。
结果
治疗后, 对照组及观察组患 者血清丙二醛(MDA)含量均降低(P<0.05), 观察组低于对照组(P<0.05); 两组血清超氧化物歧化酶(SOD)、谷胱甘肽过氧 化物酶(GSH-Px)含量均升高(P<0.05), 观察组含量均高于对照组(P<0.05); 两组血清白细胞介素(IL)-1、肿瘤坏死因子 (TNF)-α、IL-6和IL-8含量均降低(P<0.05), 观察组含量均低于对照组(P<0.05)。治疗后, 两组患者大脑中动脉收缩期血流 速度(Vs)、平均血流速度(Vm)水平升高, 搏动指数(PI)降低, 组内治疗前后差异均有统计学意义(P<0.05); 观察组Vs 及Vm水平高于对照组, PI低于对照组, 组间差异均有统计学意义(P<0.05)。治疗后两组MMSE及ADL评分均明显升高 (P<0.05), 观察组评分高于对照组(P<0.05)。
结论
推拿联合奥拉西坦治疗可改善轻度VD患者的脑部血液供应, 提高其 日常生活能力和认知能力; 其机制可能与减轻氧化应激损伤及炎症反应有关。
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Acknowledgments
This work was supported by the Project of Hebei Provincial Administration of Traditional Chinese Medicine (河北省中医药管理局项目, No. 2017002).
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The authors declare that there is no potential conflict of interest in this article.
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Informed consent was obtained from all individual participants.
Co-first Authors: GU Nan, master degree candidate of 2017; FAN Yuexian, master degree candidate of 2018
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Gu, N., Fan, Y., Zhou, L. et al. Influence of Tuina plus oxiracetam on serum inflammatory factors and oxidative stress in mild vascular dementia patients. J. Acupunct. Tuina. Sci. 20, 273–280 (2022). https://doi.org/10.1007/s11726-022-1324-6
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DOI: https://doi.org/10.1007/s11726-022-1324-6
Keywords
- Tuina
- Massage
- Cognitive Dysfunction
- Dementia, Vascular
- Activities of Daily Living
- Oxidative Stress
- Inflammatory Factors