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New insights into the tonifying kidney-yin herbs and formulas for the treatment of osteoporosis

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Abstract

Osteoporosis is characterized by an increasing osseous fragility and fracture resulting from the low mass and deteriorated microarchitecture in the bone tissue. The hormone replacement therapy and alendronate were frequently used to treat osteoporosis as the primary therapeutic strategy, but their adverse effects have severely limited their extensive clinical application, therefore, it is urgent to develop alternative or complementary therapeutic agents for anti-osteoporosis. Interestingly, with more people focusing on the complementary and alternative medicine, traditional Chinese herbs and formulas are being gradually recognized as safe and effective agents in the treatment of osteoporosis. In particular, a notable trend is that increasing studies are making efforts to clarify the anti-osteoporotic effects and mechanism of the tonifying kidney-yin herbs and formulas, a category of agents identified as effective therapy. Therefore, the purpose of this study is to comprehensively review the tonifying kidney-yin herbs and formulas that have been reported in the treatment of osteoporosis as well as how the agents play their roles in detail. This current study not only will advance our understanding of the actions of tonifying kidney-yin herbs and formulas, but also provide new evidence for the clinic use of the tonifying kidney-yin herbs and formulas in the treatment of osteoporosis.

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Abbreviations

ALP:

Alkaline phosphatase

BGP:

bone Gla protein

BMP2:

bone morphogenetic protein 2

CT:

calcitonin

CTX-I:

C-terminal telopeptide of type I collagen

DPD:

deoxypyridinoline

ERK:

extracellular signal-regulated kinase

IL-6:

interleukin-6

JNK:

c-JunN-terminal kinase

LRP5:

lipoprotein receptor-related protein 5

NFATc1:

nuclear factor of activated T cells c1

OCN:

osteocalcin

OPG:

osteoprotegerin

OPN:

osteopontin

PI3K:

phosphatidylinositol 3-kinase

RANKL:

receptor activator of NF-kB ligand

RUNX2:

Runt-related transcription factor 2

TNF-α:

Tumor Necrosis Factor-α

TRACP:

tartrate-resistant acid phosphatase

Wnt:

wingless-related MMTV integration site

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Acknowledgements

Jian-Bo He conceived the idea and wrote the manuscript paper. Ding-Kun Lin supervised the research and contributed to the final draft of the paper. Mei-Hui Chen collected the relevant literature. We thank Xiao-Juan Li and Shu-Dong Chen for the help of this manuscript. All authors reviewed and approved the final manuscript. This work was supported by National Natural Science Foundation of China (no. 81673992), and National Natural Science Foundation of China (no. 81273782).

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  1. Guangzhou University of Chinese Medicine, Guangzhou, China

    Jian-Bo He

  2. Guangdong Provincial Academy of Chinese Medical Sciences, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China

    Mei-Hui Chen

  3. Guangdong Provincial Hospital of Chinese Medicine, No. 111 Dade Road, Yuexiu District, Guangzhou, 510120, China

    Ding-Kun Lin

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  1. Jian-Bo He
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  2. Mei-Hui Chen
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Correspondence to Ding-Kun Lin.

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Jian-Bo He, Ding-Kun Lin and Mei-Hui Chen declare that they have no conflict of interest.

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He, JB., Chen, MH. & Lin, DK. New insights into the tonifying kidney-yin herbs and formulas for the treatment of osteoporosis. Arch Osteoporos 12, 14 (2017). https://doi.org/10.1007/s11657-016-0301-4

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