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Antibody–Drug Conjugates for the Treatment of Hematological Malignancies: A Comprehensive Review

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Abstract

Antibody–drug conjugates (ADCs) are an emerging class of therapeutic agents that bring new opportunities for the treatment of hematological malignancies by meeting unmet medical needs. These drugs consist of a cytotoxic agent connected by a linker to a human, humanized, or chimeric antibody targeting a surface antigen specifically expressed by tumor cells. These ADCs are being developed to specifically deliver the cytotoxic agent into tumor cells. The cytotoxic payload is released from the ADC after internalization and cleavage of the linker, ultimately triggering the death of the cancer cell. Second- and even third-generation ADCs are currently being developed and have more stable linkers and more potent payloads, which should improve ADC efficacy even further. In this review, we analyze the results for the main ADCs currently developed and discuss the advantages and drawbacks of this therapeutic option.

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Acknowledgements

We thank Philip Bastable for his English writing assistance.

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  1. Centre de Recherches en Cancérologie de Toulouse (CRCT), UMR1037 INSERM, Université Toulouse III: Paul-Sabatier, ERL5294 CNRS, Université de Toulouse, Toulouse, France

    Cédric Rossi

  2. Hématologie Clinique, Hôpital Le Bocage—CHU Dijon, 14 rue Paul Gaffarel, 21079, Dijon Cedex, France

    Cédric Rossi, Marie-Lorraine Chrétien & René-Olivier Casasnovas

  3. Faculté des Sciences de Santé, INSERM UMR1231, Dijon, France

    Marie-Lorraine Chrétien & René-Olivier Casasnovas

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R.-O. Casasnovas received honoraria from Roche, Takeda, Gilead, and research funding from Roche and Gilead, and had a consulting role for Roche, Takeda, Gilead, Abbvie, BMS, and Merck. C. Rossi had a consulting role for Takeda and research funding from Roche. M.-L. Chrétien has no disclosures to declare.

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Rossi, C., Chrétien, ML. & Casasnovas, RO. Antibody–Drug Conjugates for the Treatment of Hematological Malignancies: A Comprehensive Review. Targ Oncol 13, 287–308 (2018). https://doi.org/10.1007/s11523-018-0558-1

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